INT91431

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 9.25
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD44) plasma membrane (CD44)
Anatomy Link Frequency
lung 6
multinucleated giant cells 2
osteoclasts 2
CD44 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 78 99.96 Very High Very High Very High
Inflammation 230 93.96 High High
Snapping jaw 7 91.60 High High
cytokine 96 83.16 Quite High
COX-2 inhibitor 4 72.72 Quite High
palliative 2 66.20 Quite High
cINOD 11 64.92 Quite High
metalloproteinase 112 49.32 Quite Low
Bile 9 43.24 Quite Low
dexamethasone 15 38.24 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 65 99.96 Very High Very High Very High
Metaplasia 1 99.96 Very High Very High Very High
Carcinoma 36 99.78 Very High Very High Very High
Metastasis 140 97.46 Very High Very High Very High
Cancer 468 96.88 Very High Very High Very High
Adhesions 435 96.76 Very High Very High Very High
Fibrosis 12 96.68 Very High Very High Very High
Pneumonia 1 94.16 High High
Apoptosis 52 93.58 High High
Injury 102 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the discs showing areas of fibrocartilaginous metaplasia, CD44H expression was upregulated in fibrochondrocytes and fibroblastlike cells, especially around the chondroid tissue.
Positive_regulation (upregulated) of Gene_expression (expression) of CD44H associated with metaplasia
1) Confidence 0.69 Published 2000 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11030403 Disease Relevance 0.86 Pain Relevance 0.55
Surface expression of CD44 splice variants (vCD44) was markedly increased in PC3/OPN cells (Figure 2A, lane 2) as compared with PC3 cells (lane 1).
Positive_regulation (increased) of Gene_expression (expression) of CD44
2) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Our results demonstrate a significant increase in the surface expression of CD44 in PC3/OPN cells.
Positive_regulation (increase) of Gene_expression (expression) of CD44
3) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
These results suggest that the surface expression of CD44 is required for the activation of MMP-9.
Positive_regulation (required) of Gene_expression (expression) of CD44
4) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.05 Pain Relevance 0
Surface expression of CD44 splice variants (vCD44) was markedly increased in PC3/OPN cells (Figure 2A, lane 2) as compared with PC3 cells (lane 1).
Positive_regulation (increased) of Gene_expression (expression) of vCD44
5) Confidence 0.43 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Rho signaling is essential for CD44 surface expression in osteoclasts [32].
Positive_regulation (essential) of Gene_expression (expression) of CD44 in osteoclasts
6) Confidence 0.43 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.25 Pain Relevance 0
Metastasis to the lung following intravenous delivery of TA3/St murine mammary carcinoma cells is prevented when the carcinoma cells are transfected with sCD44-encoding cDNA, where sCD44 probably acts as a competitive inhibitor of cell surface CD44-hyaluronate interactions [216].
Positive_regulation (transfected) of Gene_expression (transfected) of sCD44 in lung associated with carcinoma and metastasis
7) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.63 Pain Relevance 0
Metastasis to the lung following intravenous delivery of TA3/St murine mammary carcinoma cells is prevented when the carcinoma cells are transfected with sCD44-encoding cDNA, where sCD44 probably acts as a competitive inhibitor of cell surface CD44-hyaluronate interactions [216].
Positive_regulation (transfected) of Gene_expression (transfected) of sCD44 in lung associated with carcinoma and metastasis
8) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.63 Pain Relevance 0
Indeed, sCD44 transfection was subsequently shown to prevent hyaluronate-mediated clustering of CD44 on tumour cell surface [60].
Positive_regulation (transfection) of Gene_expression (transfection) of sCD44 associated with cancer
9) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.72 Pain Relevance 0
Indeed, sCD44 transfection was subsequently shown to prevent hyaluronate-mediated clustering of CD44 on tumour cell surface [60].
Positive_regulation (transfection) of Gene_expression (transfection) of sCD44 associated with cancer
10) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.72 Pain Relevance 0
This activity may take place via an increase in the surface expression of MMP-9 docking protein CD44 through ?
Positive_regulation (increase) of Gene_expression (expression) of CD44
11) Confidence 0.39 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
The following observations were made in PC3/OPN cells as compared with PC3 cells: 1) an increase in multinucleated giant cells and RANKL expression; 2) an increase in CD44 surface expression, interaction of CD44/MMP-9 on the cell surface, MMP-9 activity in the conditioned medium, and cell migration; 3) western blot analysis of concentrated conditioned medium exhibited equal levels of MMP-9 protein in all PC3 cells.
Positive_regulation (increase) of Gene_expression (expression) of CD44 in multinucleated giant cells
12) Confidence 0.39 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.33 Pain Relevance 0
It is unknown whether the expression of these receptors is changed in IPF; CD44 is expressed on lung fibroblasts and epithelial cells [43], is induced in radiation- and bleomycin-induced pulmonary fibrosis [44] and in acute alveolar fibrosis [45], and is critical for resolution of noninfectious lung inflammation [46].
Positive_regulation (induced) of Gene_expression (expressed) of CD44 in lung associated with fibrosis, inflammation, pneumonia and pulmonary fibrosis
13) Confidence 0.30 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.68 Pain Relevance 0.32
These studies showed that ASM cells constitutively express high levels of CD44, the principal cell surface receptor for hyaluronate, and express intercellular adhesion molecule-1 and vascular cell-adhesion molecule-1 when stimulated with TNF-?.
Positive_regulation (levels) of Gene_expression (express) of CD44 associated with adhesions
14) Confidence 0.21 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.81 Pain Relevance 0
Loss or reduction of the E-cadherin and beta-catenin expressions and overexpression of CD44s in the round cells are suggested to be contributed to the high propensity for lymphatic permeation and poor prognosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD44s
15) Confidence 0.21 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 17033799 Disease Relevance 0.76 Pain Relevance 0.07
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Positive_regulation (have) of Gene_expression (expression) of CD44
16) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.44 Pain Relevance 0
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Positive_regulation (increased) of Gene_expression (expression) of CD44bright
17) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.43 Pain Relevance 0.03
COX-2 has been shown to contribute to both tumourigenesis and the malignant phenotype of tumour cells by different mechanisms, including (1) the inhibition of apoptosis by the activation of the PI3-Kinase/Akt pathway and increased production of PGE2, leading to increased expression of Bcl-2 and attenuation of nitric oxide signalling, (2) increased angiogenesis by increased PGE2 production with subsequent vascular endothelial growth factor production, (3) increased invasiveness by the overexpression of CD44, and (4) increased cell growth by the activation of EP receptors [8, 31].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD44 associated with malignant neoplastic disease, cancer and apoptosis
18) Confidence 0.16 Published 2006 Journal Virchows Arch Section Body Doc Link PMC1888720 Disease Relevance 1.17 Pain Relevance 0.10
Loss or reduction of the E-cadherin and beta-catenin expressions and overexpression of CD44s in the round cells are suggested to be contributed to the high propensity for lymphatic permeation and poor prognosis.
Positive_regulation (contributed) of Gene_expression (overexpression) of CD44s
19) Confidence 0.14 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 17033799 Disease Relevance 0.76 Pain Relevance 0.07

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