INT9144

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Context Info
Confidence 0.56
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 22
Disease Relevance 10.17
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSC) DNA binding (MSC)
Anatomy Link Frequency
stem cells 4
hepatocytes 3
liver 3
adipose tissue 2
spleen 1
MSC (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 31 99.98 Very High Very High Very High
Paracetamol 7 99.96 Very High Very High Very High
cytokine 37 99.20 Very High Very High Very High
chemokine 15 98.76 Very High Very High Very High
Cancer pain 5 98.28 Very High Very High Very High
Analgesic 3 94.84 High High
fibrosis 39 92.68 High High
dexamethasone 19 90.52 High High
Bioavailability 6 89.28 High High
tolerance 13 84.16 Quite High
Disease Link Frequency Relevance Heat
Obesity 117 100.00 Very High Very High Very High
Cancer 71 99.60 Very High Very High Very High
Diabetes Mellitus-type I 45 99.28 Very High Very High Very High
Severe Combined Immunodeficiency 39 98.84 Very High Very High Very High
Rheumatoid Arthritis 2 98.68 Very High Very High Very High
Cancer Pain 5 98.28 Very High Very High Very High
Injury 74 98.10 Very High Very High Very High
Hepatocellular Cancer 28 94.44 High High
Fibrosis 32 92.68 High High
Glioma 10 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded from the above results that MSC is a satisfactory sustained release morphine suppository for the treatment of cancer pain, administering it twice a day, and that MSCH is effective due to its fast analgesic effect and sustained release nature not only for cancer pain but also for surgical operations.
Localization (release) of MSC associated with cancer pain, analgesic and morphine
1) Confidence 0.56 Published 1992 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1394709 Disease Relevance 0.19 Pain Relevance 1.25
The inherent slow-release character of MSC was confirmed by 2 1/2 X T1/2 absorption rate, one-half Cmax, and twice Tmax relative to IRMS.
Localization (release) of MSC
2) Confidence 0.49 Published 1987 Journal J. Clin. Oncol. Section Abstract Doc Link 3585450 Disease Relevance 0.24 Pain Relevance 0.50
The profiles of morphine release from MST and MSC in vitro were similar, and revealed that suppository bases had no effect on the release profile of morphine from the preparation.
Localization (release) of MSC associated with morphine
3) Confidence 0.46 Published 1992 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1394709 Disease Relevance 0 Pain Relevance 0.93
In vivo, MSC were transplanted into spleen or liver of NOD/SCID mice undergoing partial hepatectomy and retrorsine treatment.
Localization (transplanted) of MSC in spleen associated with severe combined immunodeficiency
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722022 Disease Relevance 0.42 Pain Relevance 0.04
DMSO, RA, BHA, IBMX or BME were used as inducible agents, and morphologic changes of BM-MSC were rapidly observed (within few hours) with variable percentage of cell expressing neuronal markers (neuron-specific enolase, tau, neuronal nuclear antigen, [9,24,25].
Localization (changes) of BM-MSC in neuron associated with rheumatoid arthritis
5) Confidence 0.38 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.23 Pain Relevance 0.11
Independently of age, MSC transplanted into liver did not differentiate into hepatocytes but remained mesenchymal and expressed collagen and alpha smooth muscle actin (?
Neg (not) Localization (differentiate) of MSC in hepatocytes
6) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.65 Pain Relevance 0.13
Independently of age, MSC transplanted into liver did not differentiate into hepatocytes but remained mesenchymal and expressed collagen and alpha smooth muscle actin (?
Localization (transplanted) of MSC in hepatocytes
7) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.65 Pain Relevance 0.13
In some mouse models of liver injury, using either partial hepatectomy or injection of toxic agents such as CCl4 or acetaminophen, MSC engrafted into the liver and albumin expression was detected [13], [14].
Localization (engrafted) of MSC in liver associated with paracetamol and injury
8) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.65 Pain Relevance 0.19
As both aMSC and pMSC differentiate into adipocytes, CD36 seems not to be important for the in vitro differentiation of MSC into adipocytes.
Localization (differentiation) of MSC in adipocytes associated with obesity
9) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.41 Pain Relevance 0
In transplanted liver, MSC localization merged with collagen deposition.
Localization (localization) of MSC in liver
10) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.31 Pain Relevance 0.05
Further, MSC localization merges with collagen deposition in transplanted liver and no difference was observed using adult or pediatric MSC.
Localization (localization) of MSC in liver
11) Confidence 0.33 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722022 Disease Relevance 0.12 Pain Relevance 0
We present our experience of insulin replacement therapy (IRT) by co-transplantation of insulin-secreting adipose tissue derived mesenchymal stem cells (IS-AD-MSC) and cultured-bone-marrow- (CBM-) derived HSCT in 11 IDDM patients.

2.

Localization (secreting) of MSC in stem cells associated with diabetes mellitus-type i and obesity
12) Confidence 0.27 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.93 Pain Relevance 0
This is the first report of successfully treating IDDM with co-transplantation of insulin-secreting adipose tissue derived MSC and HSCT.
Localization (secreting) of MSC in adipose tissue associated with diabetes mellitus-type i and obesity
13) Confidence 0.27 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.29 Pain Relevance 0
We present our experience of cotransplantation of adipose tissue derived insulin-secreting mesenchymal stem cells (IS-AD-MSC) and cultured bone marrow (CBM) as IRT for these patients.
Localization (-) of MSC in stem cells associated with obesity
14) Confidence 0.27 Published 2010 Journal Stem Cells International Section Abstract Doc Link PMC3010655 Disease Relevance 0.69 Pain Relevance 0
We present our experience of cotransplantation of adipose tissue derived insulin-secreting mesenchymal stem cells (IS-AD-MSC) and cultured bone marrow (CBM) as IRT for these patients.
Localization (secreting) of MSC in stem cells associated with obesity
15) Confidence 0.27 Published 2010 Journal Stem Cells International Section Abstract Doc Link PMC3010655 Disease Relevance 0.69 Pain Relevance 0
We present our experience of insulin replacement therapy (IRT) by co-transplantation of insulin-secreting adipose tissue derived mesenchymal stem cells (IS-AD-MSC) and cultured-bone-marrow- (CBM-) derived HSCT in 11 IDDM patients.

2.

Localization (-) of MSC in stem cells associated with diabetes mellitus-type i and obesity
16) Confidence 0.27 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.93 Pain Relevance 0
BMMC and MSC have been extensively studied and proved to produce and secrete a broad variety of cytokines, chemokines, and growth factors, between them VEGF, FGF, HGF, IGF, adrenomedullin, thymosin ?
Localization (secrete) of MSC in HGF associated with chemokine and cytokine
17) Confidence 0.17 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.08 Pain Relevance 0.10
Studeny's group pioneered to demonstrate that MSC can be integrated into the tumor architecture, which inhibit tumor growth in vivo by local production of an anti-tumor molecule interferon (IFN-?)
Localization (integrated) of MSC associated with cancer
18) Confidence 0.16 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.78 Pain Relevance 0.05
-AET promotes differentiation of Human MSC
Localization (differentiation) of MSC
19) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.53 Pain Relevance 0.05
Among them, adipose tissue is the most promising source of MSC-like cells suitable for clinical trials.
Localization (source) of MSC in adipose tissue associated with obesity
20) Confidence 0.11 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2968415 Disease Relevance 0.77 Pain Relevance 0.03

General Comments

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