INT91445

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Context Info
Confidence 0.56
First Reported 2000
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 50
Total Number 53
Disease Relevance 38.80
Pain Relevance 7.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
retina 2
neuronal 2
mononuclear cells 2
hepatocytes 1
cleavage 1
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 131 99.84 Very High Very High Very High
fibrosis 3 99.48 Very High Very High Very High
ischemia 398 99.26 Very High Very High Very High
amygdala 12 99.24 Very High Very High Very High
Glutamate 578 99.00 Very High Very High Very High
glial activation 8 98.60 Very High Very High Very High
cINOD 22 98.48 Very High Very High Very High
depression 4 96.32 Very High Very High Very High
Eae 12 96.08 Very High Very High Very High
antidepressant 10 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1592 100.00 Very High Very High Very High
Alzheimer's Dementia 6 99.80 Very High Very High Very High
Stress 209 99.68 Very High Very High Very High
Cancer 131 99.60 Very High Very High Very High
Death 544 99.58 Very High Very High Very High
Chordoma 4 99.48 Very High Very High Very High
Fibrosis 3 99.48 Very High Very High Very High
Injury 172 99.32 Very High Very High Very High
Retina Disease 153 99.26 Very High Very High Very High
Drug Induced Neurotoxicity 8 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first considered the regulation of several Bcl-2 family genes at time 0, 3, and 24 h in control retinas from anesthetized animals and from anesthetized animals in which a needle had been inserted and kept in place for 1 h, but without initiating any increase in IOP.
Regulation (regulation) of Bcl-2 in retinas associated with ocular hypertension
1) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.60 Pain Relevance 0.21
We then focused on the kinetics of the response and compared the modulation of the Bcl-2 family members between the early (3 h) and late (24 h) phases post I/R.
Regulation (modulation) of Bcl-2
2) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.15 Pain Relevance 0
In summary, the current study reports a novel regulation of Bcl-2-related family members following retinal ischemia.
Regulation (regulation) of Bcl-2 associated with ischemia and retina disease
3) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.76 Pain Relevance 0.17
The regulation of Bcl-2 has widely been considered in the study of the retina as well as in cerebral ischemia.
Regulation (regulation) of Bcl-2 in retina associated with cv general 4 under development and ischemia
4) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.89 Pain Relevance 0.36
The present study examined the regulation of the major antiapoptotic (Bcl-2, Bcl-xl) and proapoptotic (Bax) genes by repeated unpredictable stress (an animal model of depression) and antidepressant treatments (ADT).
Spec (examined) Regulation (regulation) of Bcl-2 associated with stress, antidepressant and depression
5) Confidence 0.55 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.82 Pain Relevance 0.38
These same investigators assessed the relationship between clinical response, plasma and intracellular oblimersen levels, and changes in bcl-2 mRNA and Bcl-2 protein levels in bone marrow mononuclear cells in 22 elderly patients treated with oblimersen and chemotherapy for previously untreated acute myeloid leukemia (Marcucci et al 2005).
Regulation (changes) of bcl-2 in mononuclear cells associated with leukemia
6) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.22 Pain Relevance 0
In contrast, nonresponding patients showed upregulation of bcl-2mRNA and no change in Bcl-2 protein levels.
Neg (no) Regulation (change) of Bcl-2
7) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.69 Pain Relevance 0
It clearly finds an association with an increase in Bax with a decrease in Bcl-xL expression and negates any involvement of Bak and Bcl-2 regulations in the damage induced by retinal ischemia 24 h after reperfusion.
Regulation (regulations) of Bcl-2 associated with ischemia and retina disease
8) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.71 Pain Relevance 0.17
The selective regulation of Bcl-xl and Bax in hippocampal subfields and of Bcl-2 in the Cg cortex, amygdala, and hypothalamus suggests that these cellular adaptations contribute to the long-term neural plastic adaptations to stress and ADTs in cortical, hypothalamic, and limbic brain structures.
Regulation (regulation) of Bcl-2 in brain structures associated with stress and amygdala
9) Confidence 0.40 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.84 Pain Relevance 0.59
In a 6-hydroxydopamine (6-OHDA)-induced Parkinson's rat model, intracerebral peripheral blood stem cell (CD34(+)) (PBSC) transplantation significantly protected dopaminergic neurons from 6-OHDA-induced neurotoxicity, enhanced neural repair of tyrosine hydroxylase neurons through up-regulation of Bcl-2, facilitated stem cell plasticity, and attenuated activation of microglia, in comparison with vehicle-control rats.
Regulation (regulation) of Bcl-2 in neural associated with drug induced neurotoxicity
10) Confidence 0.31 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19235891 Disease Relevance 0.44 Pain Relevance 0.08
Regulators of these processes such as ODC, Bcl-2, VEGF and EGF receptor are likely to be involved in the healing action of L. rhamnosus GG for gastric ulcer.
Regulation (Regulators) of Bcl-2 associated with peptic ulcer
11) Confidence 0.27 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.07 Pain Relevance 0.05
Developmental A1254 exposure had no effect on cortical or striatal levels of Bcl2 mRNA in either sex at PND7 (Figure 5A,C).
Neg (no) Regulation (effect) of Bcl2
12) Confidence 0.26 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.12 Pain Relevance 0
However, these data do not rule out the possibility that PCBs confer protection against ischemic injury by preconditioning, because preconditioning can be elicited by mechanisms other than Bcl2 and Cyp2C11 up-regulation, including increased oxygen free radicals, calcium influx via N-methyl-D-aspartate (NMDA) receptors, and proinflammatory cytokines (Koerner and Alkayed 2007).
Regulation (regulation) of Bcl2 associated with injury and cytokine
13) Confidence 0.26 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.10 Pain Relevance 0.05
Therefore, increase in the expression of Bcl-2 may determine survival following apoptotic stimuli and attenuate the antiapoptotic effect of Bcl-2 gene by reducing postischemic apoptosis.[16] However, attempts to protect against hepatic I/R injury by alleviating the possible detrimental effects of portal venous congestion have not achieved satisfactory results.
Regulation (effect) of Bcl-2 associated with hyperemia, injury and apoptosis
14) Confidence 0.26 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 1.33 Pain Relevance 0.06
On the other hand, MnSOD is a major mitochondrial antioxidant enzyme involved in the suppression of apoptosis, via regulation of the Bcl-2 family proteins such as Bcl-2 and Bax (26, 27).
Regulation (regulation) of Bcl-2 associated with apoptosis
15) Confidence 0.26 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.91 Pain Relevance 0.03
On the other hand, MnSOD is a major mitochondrial antioxidant enzyme involved in the suppression of apoptosis, via regulation of the Bcl-2 family proteins such as Bcl-2 and Bax (26, 27).
Regulation (regulation) of Bcl-2 associated with apoptosis
16) Confidence 0.26 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.90 Pain Relevance 0.03
This study revealed that Bcl-2-related family members were differently regulated in the early and late phases after an ischemic insult.
Regulation (regulated) of Bcl-2
17) Confidence 0.25 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2765238 Disease Relevance 0.49 Pain Relevance 0.13
To unravel the mechanisms involved in the apoptotic process induced after retinal ischemia, we assessed whether members of the Bcl-2 family of genes were regulated early (3 h) or late (24 h) after I/R, both at the mRNA and protein levels.
Spec (whether) Regulation (regulated) of Bcl-2 associated with ischemia, apoptosis and retina disease
18) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.20 Pain Relevance 0.14
The observation that neither the Bax:Bcl-2 nor the Bax:Bcl-xL ratios are regulated at a time when apoptosis is already detectable (3 h) suggests that Bcl-2-related family members are not associated with early cell death following I/R.
Neg (neither) Regulation (regulated) of Bcl-2 associated with apoptosis and death
19) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.07
Semi-quantitative analysis showed significant down regulation of Bcl-2 gene and upregulation of Bax gene expressions following arsenic exposure.
Regulation (regulation) of Bcl-2
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.64 Pain Relevance 0

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