INT91456

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Context Info
Confidence 0.17
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.36
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) aging (IL1B)
cytoplasm (CPOX) cell-cell signaling (IL1B) cytosol (IL1B)
Anatomy Link Frequency
HMSM 2
SK-N-SH 2
IL1B (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
dexamethasone 2 99.76 Very High Very High Very High
rheumatoid arthritis 140 99.64 Very High Very High Very High
cINOD 18 90.88 High High
Pain 2 74.64 Quite High
COX-2 inhibitor 12 67.56 Quite High
antagonist 1 54.28 Quite High
COX2 6 25.00 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 140 99.64 Very High Very High Very High
Death 30 99.60 Very High Very High Very High
Cancer 16 99.52 Very High Very High Very High
Necrosis 6 99.04 Very High Very High Very High
Neuroblastoma 6 94.04 High High
Osteogenic Sarcomas 4 93.40 High High
Apoptosis 94 93.20 High High
Dementia 2 87.20 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 86.28 High High
Disease 14 79.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1beta stimulated release of PGE(2) by HMSM cells and increased COX-2 and mPGES-1 mRNA and protein expression.
IL-1beta Positive_regulation (increased) of Gene_expression (expression) of COX in HMSM
1) Confidence 0.17 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.05 Pain Relevance 0.13
Our data suggest that IL-1beta-induced COX-2 expression in SK-N-SH cells is regulated by different mechanisms, presumably involving mRNA transcription and mRNA stability.
IL-1beta-induced Positive_regulation (induced) of Gene_expression (expression) of COX in SK-N-SH
2) Confidence 0.10 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.44 Pain Relevance 0.11
We further demonstrate that both a free radical scavenger and an inhibitor of p38 mitogen-activated protein kinase (MAPK) reduce IL-1beta-induced synthesis of COX-2.
IL-1beta-induced Positive_regulation (induced) of Gene_expression (synthesis) of COX
3) Confidence 0.10 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.47 Pain Relevance 0.12
It has been previously suggested that both COX-1 and COX-2 are expressed by human RA FLS and that the expression of COX-2 messenger RNA and protein is enhanced by proinflammatory cytokines such as IL-1?
IL-1 Positive_regulation (enhanced) of Gene_expression (expression) of COX associated with rheumatoid arthritis and cytokine
4) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 1.28 Pain Relevance 0.21
We also studied whether COX-2 induction with IL-1?
IL-1 Positive_regulation (induction) of Gene_expression (studied) of COX
5) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.85 Pain Relevance 0.12
Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.
IL-1beta Positive_regulation (induced) of Gene_expression (expression) of COX associated with dexamethasone
6) Confidence 0.02 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.13 Pain Relevance 0.42
Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.
IL-1beta Positive_regulation (induced) of Gene_expression (expression) of COX associated with dexamethasone
7) Confidence 0.02 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.13 Pain Relevance 0.42

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