INT9146

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 10.76
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (FOLH1) plasma membrane (FOLH1) nucleus (FOLH1)
cytoplasm (FOLH1)
Anatomy Link Frequency
coronary artery 2
myocardium 1
blood 1
cytotoxic T lymphocytes 1
FOLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 11 100.00 Very High Very High Very High
imagery 105 99.84 Very High Very High Very High
Acupuncture 16 99.64 Very High Very High Very High
ischemia 30 98.64 Very High Very High Very High
Catechol-O-methyltransferase 109 95.60 Very High Very High Very High
Pain 30 89.64 High High
Arthritis 55 88.28 High High
Glutamate receptor 1 77.36 Quite High
Analgesic 10 75.00 Quite High
rheumatoid arthritis 4 72.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 748 100.00 Very High Very High Very High
Reprotox - General 1 4 100.00 Very High Very High Very High
Recurrence 13 99.72 Very High Very High Very High
Malaria 30 99.12 Very High Very High Very High
Carcinoma 144 98.80 Very High Very High Very High
Cv Unclassified Under Development 35 98.64 Very High Very High Very High
Disease 99 98.40 Very High Very High Very High
Stress 37 98.12 Very High Very High Very High
Hantavirus Infection 78 96.32 Very High Very High Very High
Coronary Artery Disease 32 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g/ml G418, positive cells expressing PSMA were identified as follows.


Gene_expression (expressing) of PSMA
1) Confidence 0.75 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0.16 Pain Relevance 0
GCPII was originally cloned as PSMA, an M(r) 100,000 type II transmembrane glycoprotein highly expressed in prostate tissues.
Gene_expression (expressed) of PSMA
2) Confidence 0.75 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 15027864 Disease Relevance 0.08 Pain Relevance 0.30
The expression of PSMA is down-regulated by androgen, after androgen deprivation therapy, its expression is strongly elevated[6,26-28], Thus, PSMA is a potential target for the immunotherapy to carcinoma of prostate.
Gene_expression (expression) of PSMA associated with carcinoma
3) Confidence 0.75 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 1.25 Pain Relevance 0
Detection of PSMA protein by Western Blot
Gene_expression (Detection) of PSMA
4) Confidence 0.75 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0 Pain Relevance 0
Detection of PSMA protein
Gene_expression (Detection) of PSMA
5) Confidence 0.75 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0.16 Pain Relevance 0
The higher rate of PSM appearance and better acupuncture effect were observed, in patients with compound sensation, such as sourness-distension and distension-numbness.
Gene_expression (appearance) of PSM associated with hypesthesia and acupuncture
6) Confidence 0.72 Published 1992 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 1394963 Disease Relevance 0.27 Pain Relevance 0.41
Two representative glutamate carboxypeptidase II (GCP II) inhibitors, 2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid 2 and 2-(3-mercaptopropyl)pentanedioic acid 3, were synthesized in high optical purities (>97%ee).
Gene_expression (synthesized) of GCP II associated with glutamate
7) Confidence 0.72 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15801825 Disease Relevance 0 Pain Relevance 0.11
Two representative glutamate carboxypeptidase II (GCP II) inhibitors, 2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid 2 and 2-(3-mercaptopropyl)pentanedioic acid 3, were synthesized in high optical purities (>97%ee).
Gene_expression (synthesized) of glutamate carboxypeptidase II associated with glutamate
8) Confidence 0.72 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15801825 Disease Relevance 0 Pain Relevance 0.11
PSMA is a well-defined prostate-restricted tumor associated antigen whose expression is significantly elevated in carcinoma of prostate, especially in advanced stages.
Gene_expression (expression) of PSMA associated with cancer and carcinoma
9) Confidence 0.65 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 1.22 Pain Relevance 0
Detection of PSMA protein
Gene_expression (Detection) of PSMA
10) Confidence 0.65 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0.16 Pain Relevance 0
Detection of PSMA protein by Western Blot
Gene_expression (Detection) of PSMA
11) Confidence 0.65 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0 Pain Relevance 0
We utilized a DNA-based vaccine to specifically enhance PSMA expression.
Gene_expression (expression) of PSMA
12) Confidence 0.58 Published 2004 Journal J Transl Med Section Abstract Doc Link PMC517950 Disease Relevance 0.53 Pain Relevance 0
In this study, we designed a DNA vaccine expressing prostate specific membrane antigen (PSMA) and utilized CpG oligodeoxynucleotides to promote Th1-type immune response.
Gene_expression (expressing) of PSMA
13) Confidence 0.58 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0.56 Pain Relevance 0
In addition, the suppression of in vivo growth of tumor cells expressing PSMA was augmented by CpG oligodeoxynucleotides.
Gene_expression (expressing) of PSMA associated with cancer
14) Confidence 0.58 Published 2004 Journal J Transl Med Section Abstract Doc Link PMC517950 Disease Relevance 0.65 Pain Relevance 0
The eukaryotic expression plasmid pCDNA3.1-PSMA encoding full-length PSMA was constructed by cloning the BamH I /Xho I fragment of pBluescipt-PSMA as described previously [18] into the pCDNA3.1 vector (Invitrogen Corp, Carlsbad, CA) cut with identical endonuclease.
Gene_expression (expression) of PSMA
15) Confidence 0.58 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0 Pain Relevance 0
Vaccine-specific cytotoxic T lymphocytes reactive with B16 cells expressing PSMA could be induced with this treatment schedule.
Gene_expression (expressing) of PSMA in cytotoxic T lymphocytes
16) Confidence 0.58 Published 2004 Journal J Transl Med Section Abstract Doc Link PMC517950 Disease Relevance 0.85 Pain Relevance 0
The results showed the kind of needling sensation while acupuncture had close relation with the appearance of PSM and the acupuncture effect.
Gene_expression (appearance) of PSM associated with acupuncture
17) Confidence 0.56 Published 1992 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 1394963 Disease Relevance 0.25 Pain Relevance 0.44
We hypothesized that PSM during DSE would predict recovery of dysfunctional myocardium after successful percutaneous coronary intervention (PCI).


Gene_expression (during) of PSM in myocardium
18) Confidence 0.16 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2790124 Disease Relevance 0.36 Pain Relevance 0.27
Post-systolic motion (PSM) detected by DMI is related to peri-infarct ischemia during DSE.
Gene_expression (detected) of PSM associated with ischemia and imagery
19) Confidence 0.14 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2790124 Disease Relevance 0.37 Pain Relevance 0.27
Nevertheless, the present results suggest that PSM during DSE predicts functional recovery of dysfunctional myocardium after successful PCI in patients with chronic coronary artery disease.



Gene_expression (during) of PSM in coronary artery associated with coronary artery disease
20) Confidence 0.14 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2790124 Disease Relevance 0.10 Pain Relevance 0.13

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