INT91462

Context Info Confidence 0.67 First Reported 2000 Last Reported 2011 Negated 2 Speculated 4 Reported most in Abstract Documents 99 Total Number 106 Disease Relevance 40.28 Pain Relevance 18.99

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1) DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)

Anatomy Link Frequency myometrium 6 fibroblast 6 epithelial cells 4 BxPC-3 3 dendrites 2 MAPK1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 425 100.00 agonist 321 100.00 bradykinin 49 100.00 Kinase C 10 100.00 cytokine 722 99.98 Dopamine 78 99.98 COX-2 inhibitor 17 99.98 Cannabinoid 15 99.82 Paracetamol 13 99.72 Enkephalin 12 99.52

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 589 99.84 Cancer 467 99.84 Chronic Hepatitis 31 99.84 Hepatocellular Cancer 11 99.84 Metaplasia 56 99.74 Infection 114 99.68 Adhesions 435 99.60 Neuroblastoma 187 99.60 Carcinoid 9 99.58 Colon Cancer 215 99.48

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Treatment of carcinoid tumor cells with ZM336372 resulted in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2.

Positive_regulation (resulted) of Phosphorylation (phosphorylation) of mitogen-activated protein kinase 1 associated with carcinoid

1) Confidence 0.67 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15956248 Disease Relevance 0.99 Pain Relevance 0.06

The decreased phosphorylation of extracellular signal-regulated kinase (ERK) was induced by JEV infection and the decrease in ERK was reversed by salicylate.

Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK associated with infection

2) Confidence 0.66 Published 2002 Journal J. Gen. Virol. Section Abstract Doc Link 12124453 Disease Relevance 0.75 Pain Relevance 0.58

Growth inhibitory concentrations of NSAIDs unexpectedly increased ERK phosphorylation in BxPC-3 and MIA PaCa-2 cells.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK in BxPC-3

3) Confidence 0.65 Published 2003 Journal Pancreas Section Body Doc Link 14576498 Disease Relevance 0.15 Pain Relevance 0

BK treatment resulted in the phosphorylation of p38 MAPK and extracellular signal-regulated kinase (ERK)1/2, and 2-APB could suppress BK-induced phosphorylation of ERK1/2.

Positive_regulation (resulted) of Phosphorylation (phosphorylation) of ERK associated with bradykinin

4) Confidence 0.60 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.31 Pain Relevance 0.63

Formyl-methionyl-leucyl-phenylalanine (fMLP) has been shown to induce the p38 MAPK phosphorylation during the respiratory burst in human neutrophils.

Positive_regulation (induce) of Phosphorylation (phosphorylation) of p38 in neutrophils

5) Confidence 0.60 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.17 Pain Relevance 0.33

The above data imply that gestational stretch due to the growing fetus, and, in vitro stretch imposed experimentally on the human myometrium, can induce ERK and CaD phosphorylation.

Positive_regulation (induce) of Phosphorylation (phosphorylation) of ERK in myometrium

6) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.25 Pain Relevance 0

The reduced sensitivity for inhibited DNA synthesis in all cases could be correlated with metaplasia which shows enhanced ERK phosphorylation in response to cytokine treatment (example of dysplastic cells in Fig. 7C).

Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of ERK associated with metaplasia and cytokine

7) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.16 Pain Relevance 0.05

In the 23 preneoplastic cell cultures, the basal level of phosphorylated ERK was increased to 22 ± 27% of the OSM value (p = 0.07).

Positive_regulation (increased) of Phosphorylation (phosphorylated) of ERK

8) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.26 Pain Relevance 0.08

Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.

Positive_regulation (factor-induced) of Phosphorylation (phosphorylation) of extracellular-regulated kinase in colon associated with colon cancer

9) Confidence 0.49 Published 2003 Journal Cancer Res. Section Title Doc Link 12566304 Disease Relevance 1.43 Pain Relevance 0.17

Moreover, in vitro studies in Panc-1 cells show that activation of VEGFR1 by VEGFB to increase mitogen-activated protein kinase 1/2 phosphorylation and cell migration on collagen-coated plates is also inhibited by tolfenamic acid.

Positive_regulation (increase) of Phosphorylation (phosphorylation) of mitogen-activated protein kinase 1

10) Confidence 0.49 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409437 Disease Relevance 0.57 Pain Relevance 0.07

In conclusion, our study showed that growth inhibitory concentrations of selective COX-1 and COX-2 inhibitors increased ERK1/2 phosphorylation in hepatoma cells, and that inhibition of the MEK/ERK signaling pathway potentiates the antitumor activity of both types of inhibitors.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK associated with hepatocellular cancer and cox-2 inhibitor

11) Confidence 0.49 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.68 Pain Relevance 0.38

These results suggest that ARE sequences in the 3'UTR of the NAG-1 gene contribute to mRNA degradation and ERK1/2 phosphorylation is responsible for the stabilization of NAG-1 mRNA.

Positive_regulation (responsible) of Phosphorylation (phosphorylation) of ERK

12) Confidence 0.49 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731769 Disease Relevance 0.38 Pain Relevance 0.05

Gabapentin (120 and 240 microM) also concentration-dependently inhibited collagen (1 microg mL(-1))-induced phosphoinositide breakdown, intracellular Ca(2+) mobilization, thromboxane A(2) formation, and p38 MAPK phosphorylation in human platelets.

Positive_regulation (-induced) of Phosphorylation (phosphorylation) of p38 in platelets associated with gabapentin

13) Confidence 0.49 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883897 Disease Relevance 0.08 Pain Relevance 0.76

BK treatment resulted in the phosphorylation of p38 MAPK and extracellular signal-regulated kinase (ERK)1/2, and 2-APB could suppress BK-induced phosphorylation of ERK1/2.

Positive_regulation (suppress) of Phosphorylation (phosphorylation) of ERK associated with bradykinin

14) Confidence 0.49 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.31 Pain Relevance 0.61

We found (Fig. 1C) that h-CaD phosphorylation at an ERK specific site (Ser 789) increases significantly in human myometrial tissue from pregnant women in labor (1.97±0.24 vs. 1.01±0.27 in NP group) but not from those not in labor (1.3±0.39).

Positive_regulation (increases) of Phosphorylation (phosphorylation) of ERK

15) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0

The decreased phosphorylation of extracellular signal-regulated kinase (ERK) was induced by JEV infection and the decrease in ERK was reversed by salicylate.

Positive_regulation (induced) of Phosphorylation (phosphorylation) of extracellular signal-regulated kinase associated with infection

16) Confidence 0.48 Published 2002 Journal J. Gen. Virol. Section Abstract Doc Link 12124453 Disease Relevance 0.75 Pain Relevance 0.58

In tumor cells, activation of extracellular-regulated kinase (ERK) 1/2 results in phosphorylation of several ERK1/2 effectors, including the proapoptotic protein Bad.

Positive_regulation (activation) of Phosphorylation (phosphorylation) of ERK associated with cancer

17) Confidence 0.46 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.50 Pain Relevance 0.17

Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein.

Positive_regulation (induce) of Phosphorylation (phosphorylation) of ERK associated with enkephalin

18) Confidence 0.45 Published 2006 Journal Brain Res. Section Title Doc Link 16854387 Disease Relevance 0 Pain Relevance 0.20

Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.

Positive_regulation (indomethacin-induced) of Phosphorylation (phosphorylation) of p38

19) Confidence 0.44 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.61 Pain Relevance 0.05

Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38

20) Confidence 0.44 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.60 Pain Relevance 0

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