INT91471

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.88
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Anatomy Link Frequency
microglia 2
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 14 100.00 Very High Very High Very High
GABAergic 3 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
tetrodotoxin 2 100.00 Very High Very High Very High
Glutamate receptor 1 100.00 Very High Very High Very High
Glutamate 2 99.00 Very High Very High Very High
dorsal root ganglion 164 98.96 Very High Very High Very High
Neuropathic pain 8 96.00 Very High Very High Very High
hyperexcitability 28 95.48 Very High Very High Very High
Spinal cord 5 94.28 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 187 98.96 Very High Very High Very High
Heart Rate Under Development 1 98.20 Very High Very High Very High
Drug Induced Neurotoxicity 5 97.12 Very High Very High Very High
Neuropathic Pain 8 96.00 Very High Very High Very High
Pressure And Volume Under Development 2 95.16 Very High Very High Very High
Injury 15 91.92 High High
Pain 18 89.88 High High
Disease 3 86.44 High High
Nociception 12 84.76 Quite High
Hyperalgesia 50 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bilateral microinjection of the ionotropic glutamate receptor antagonist kynurenic acid (1 nmol) and the Na(+) channel blocker tetrodotoxin (10 pmol) into the region of the vlNTS consistently produced a similar prolongation of inspiratory duration and an apneustic pattern of breathing.
Positive_regulation (produced) of Gene_expression (microinjection) of channel associated with tetrodotoxin, antagonist and glutamate receptor
1) Confidence 0.22 Published 2000 Journal Brain Res. Section Abstract Doc Link 11032996 Disease Relevance 0.19 Pain Relevance 0.27
The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro

Background

Positive_regulation (activated) of Gene_expression (expressed) of channel in microglia associated with drug induced neurotoxicity
2) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Title Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0
The enhancement of GABAergic but not glycinergic transmission was largely depressed by Na(+) channel blocker tetrodotoxin or glutamate-receptor antagonists (6-cyano-7-nitroquinoxaline-2,3-dione and/or dl-2-amino-5-phosphonovaleric acid) and also in a Ca(2+)-free Krebs solution.
Positive_regulation (enhancement) of Gene_expression (depressed) of channel associated with tetrodotoxin, glutamate, antagonist and gabaergic
3) Confidence 0.04 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18216222 Disease Relevance 0.08 Pain Relevance 0.55
The expression of the channel was induced either immediately or three days after the onset of a chronic compression of the DRG (CCD model of neuropathic pain).
Positive_regulation (induced) of Gene_expression (expression) of channel associated with dorsal root ganglion and neuropathic pain
4) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959023 Disease Relevance 1.42 Pain Relevance 1.11
We used an inducible adenoviral vector to transfer the inwardly rectifying potassium channel Kir2.1 directly into the DRG under compression.
Positive_regulation (transfer) of Gene_expression (transfer) of channel associated with dorsal root ganglion and potassium channel
5) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959023 Disease Relevance 0.99 Pain Relevance 0.61

General Comments

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