INT91475

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 0.61
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDOR1) oxidoreductase activity (NDOR1) cell death (NDOR1)
nucleus (NDOR1) cytoplasm (NDOR1)
Anatomy Link Frequency
tail 1
VMN 1
NDOR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 423 100.00 Very High Very High Very High
Spinal cord 4 99.80 Very High Very High Very High
nMDA receptor 72 99.24 Very High Very High Very High
tetrodotoxin 1 98.96 Very High Very High Very High
sNRI 63 98.76 Very High Very High Very High
sSRI 153 96.92 Very High Very High Very High
fluoxetine 36 96.68 Very High Very High Very High
antagonist 36 94.72 High High
tricyclic antidepressant 90 94.64 High High
Serotonin 27 93.12 High High
Disease Link Frequency Relevance Heat
Frailty 4 97.60 Very High Very High Very High
Injury 2 93.20 High High
Neurodegenerative Disease 9 77.36 Quite High
Disease 18 5.00 Very Low Very Low Very Low
Schizophrenia 10 5.00 Very Low Very Low Very Low
Epilepsy 9 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Stroke 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found increased NR1 and NR2A mRNAs in VMN similar in extent to that seen after SCI.
NR1 Binding (found) of in VMN associated with frailty
1) Confidence 0.27 Published 2000 Journal Brain Res. Section Abstract Doc Link 11033004 Disease Relevance 0.54 Pain Relevance 0.35
Furthermore, overexpression of mini-genes encoding either NR1 or D1 carboxyl tail fragments disrupts the D1-NR1 direct protein-protein interaction and abolishes NMDA-induced changes in both D1 cell surface expression and D1-mediated cAMP accumulation.
NR1 Binding (interaction) of in tail
2) Confidence 0.04 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.49
direct binding to the extracellular S1S2 domain of the NMDA NR1-1b subunit may
NR1 Binding (binding) of
3) Confidence 0.03 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.57
bound to the S1S2 domain of the NR1-1b subunit of the NMDA receptor, but did
NR1 Binding (bound) of associated with nmda receptor
4) Confidence 0.03 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.49
Figure 2, bind to the S1S2 domain of the NR1-1b subunit of the NMDA receptor.
NR1 Binding (bind) of associated with nmda receptor
5) Confidence 0.03 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0.08 Pain Relevance 1.00
venlafaxine, the former two that showed evidence of binding to the NR1-1b S1S2
NR1 Binding (binding) of
6) Confidence 0.03 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.26
NR1-1b S1S2 and in the antidepressant bound NR1-1b S1S2 domains.
NR1 Binding (bound) of associated with antidepressant
7) Confidence 0.03 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.38
presented for the ANS bound NR1-1b S1S2-imipramine complex.
NR1 Binding (bound) of
8) Confidence 0.03 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.58
intensity) of the apo NMDA NR1-1b S1S2 domain to antidepressant bound
NR1 Binding (intensity) of associated with antidepressant
9) Confidence 0.02 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.30
ground state NMDA NR1-1b S1S2 domain: antidepressant complexes, and could be
NR1 Binding (ground) of associated with antidepressant
10) Confidence 0.02 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.28
ground state NMDA NR1-1b S1S2 domain: antidepressant complexes, and could be
NR1 Binding (complexes) of associated with antidepressant
11) Confidence 0.02 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.28

General Comments

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