INT91476

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDOR1) oxidoreductase activity (NDOR1) cell death (NDOR1)
nucleus (NDOR1) cytoplasm (NDOR1)
Anatomy Link Frequency
VMN 2
NDOR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 9 100.00 Very High Very High Very High
Spinal cord 8 99.56 Very High Very High Very High
tetrodotoxin 2 98.72 Very High Very High Very High
antidepressant 47 97.72 Very High Very High Very High
sSRI 17 77.12 Quite High
tricyclic antidepressant 10 76.64 Quite High
Glutamate receptor 5 75.00 Quite High
Desipramine 11 73.44 Quite High
Nortriptyline 11 63.04 Quite High
sNRI 7 35.72 Quite Low
Disease Link Frequency Relevance Heat
Frailty 8 97.60 Very High Very High Very High
Injury 4 92.96 High High
Disease 2 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found increased NR1 and NR2A mRNAs in VMN similar in extent to that seen after SCI.
Positive_regulation (increased) of NR1 in VMN associated with frailty
1) Confidence 0.50 Published 2000 Journal Brain Res. Section Abstract Doc Link 11033004 Disease Relevance 0.53 Pain Relevance 0.35
Previously we reported up-regulation of NMDA receptor subunits NR1 and NR2A mRNAs in VMN caudal to the lesion site 24 h after SCI.
Positive_regulation (regulation) of NR1 in VMN associated with nmda receptor and frailty
2) Confidence 0.34 Published 2000 Journal Brain Res. Section Abstract Doc Link 11033004 Disease Relevance 0.54 Pain Relevance 0.32
S1S2 domain and caused a change in the environment of the NR1-1b S1S2
Positive_regulation (environment) of NR1
3) Confidence 0.04 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2809336 Disease Relevance 0 Pain Relevance 0.33

General Comments

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