INT91491

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.93
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (AMT) cytoplasm (AMT)
AMT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 98.72 Very High Very High Very High
antagonist 2 95.32 Very High Very High Very High
Glutamate receptor 2 94.84 High High
Cannabinoid 62 93.40 High High
Glutamate 24 90.20 High High
qutenza 10 89.80 High High
depression 273 84.08 Quite High
Dopamine 166 81.28 Quite High
Ventral tegmentum 32 76.24 Quite High
GABAergic 20 59.12 Quite High
Disease Link Frequency Relevance Heat
Disease 68 97.84 Very High Very High Very High
Appetite Loss 60 94.64 High High
Cognitive Disorder 96 88.80 High High
Congenital Anomalies 4 86.24 High High
Depression 285 84.08 Quite High
Parkinson's Disease 6 75.92 Quite High
Injury 63 71.76 Quite High
Stress 19 59.04 Quite High
Death 8 55.08 Quite High
Neurological Disease 6 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we tested several AEA derivatives containing various derivatized phenyl groups or different alkyl chains as either inhibitors of the AEA membrane transporter (AMT) in intact cells or functional agonists of the VR1 vanilloid receptor in HEK cells transfected with the human VR1.
Negative_regulation (inhibitors) of AMT associated with agonist
1) Confidence 0.39 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 11033355 Disease Relevance 0 Pain Relevance 0.34
The rationale for the present series of studies was therefore to investigate systematically for the first time the extent to which reduced AMS on the AMT is an example of poor task performance on a paradigm that loads significantly on executive control and that is associated with depressed mood and/or various clinical states.
Negative_regulation (reduced) of AMT
2) Confidence 0.32 Published 2007 Journal J Exp Psychol Gen Section Body Doc Link PMC2225543 Disease Relevance 0.36 Pain Relevance 0.04
We found that four known AMT inhibitors, AM404, arvanil, olvanil and linvanil, activate VR1 receptors at concentrations 400-10000-fold lower than those necessary to inhibit the AMT.
Negative_regulation (inhibitors) of AMT
3) Confidence 0.29 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 11033355 Disease Relevance 0 Pain Relevance 0.36
Using a stratified sample in Study 5, the authors confirmed the positive association between depressed mood and impaired performance on the AMT.
Negative_regulation (impaired) of AMT
4) Confidence 0.23 Published 2007 Journal J Exp Psychol Gen Section Abstract Doc Link PMC2225543 Disease Relevance 0.22 Pain Relevance 0.06
This allowed us in this reanalysis of the data to examine the degree to which verbal fluency was associated with reduced AMS on the AMT.
Negative_regulation (reduced) of AMT
5) Confidence 0.23 Published 2007 Journal J Exp Psychol Gen Section Body Doc Link PMC2225543 Disease Relevance 0.18 Pain Relevance 0.03
Accordingly, increased levels of AEA [47, 54, 80, 115] together with a downregulation of AMT and FAAH have been found in an experimental model of PD [54, 80, 115], indicating that the eCB system undergoes complex plastic changes leading to/during PD.
Negative_regulation (downregulation) of AMT associated with disease
6) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0.69 Pain Relevance 0.31
Karianan et al., in fact, indicate how disruption of the two distinct mechanisms of eCB inactivation, combining transport and FAAH inhibitors AM404 and AM374, causesadditive effects mediated by potentiation of eCB tone acting on CB1 receptors.Accordingly, by enhancing AEA availability, through inhibition of AMT and FAAH, most deficits (e.g. akinesia and sensorimotor orientation) were ameliorated in an experimental model of PD [54].
Negative_regulation (inhibition) of AMT associated with disease
7) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0.47 Pain Relevance 0.19

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