INT915
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In order to ascertain whether there is a relation between opioids and the serotoninergic system in prolactin (PRL) secretion increase, we investigated in seven healthy men (21 to 26 years of age) the effect of naloxone, a specific opioid antagonist, on PRL secretion induced by fenfluramine, a drug that stimulates serotonin release and inhibits its re-uptake. | |||||||||||||||
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We observed that subjects receiving fenfluramine (60 mg orally) had a significantly (P less than 0.001) higher increase in PRL plasma levels than the controls receiving placebo. | |||||||||||||||
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In order to ascertain whether there is a relation between opioids and the serotoninergic system in prolactin (PRL) secretion increase, we investigated in seven healthy men (21 to 26 years of age) the effect of naloxone, a specific opioid antagonist, on PRL secretion induced by fenfluramine, a drug that stimulates serotonin release and inhibits its re-uptake. | |||||||||||||||
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Intravenous administration of 2,5 mg/kg piperoxane produced a rapid and significant increase in serum PRL concentrations in four non-human primates. | |||||||||||||||
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Activation of the stress response in meerkats by capture and ketamine hydrochloride anesthesia caused short-term but significant increases in prolactin levels in individuals bled repeatedly. | |||||||||||||||
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FK 33-824 significantly (P < 0.001) increased Prl and FWC and reduced urinary concentrations of AVP (P < 0.01). | |||||||||||||||
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His serum PRL levels were slightly elevated (38 ng/ml), whereas concentrations of the other adenohypophysial hormones were within normal range. | |||||||||||||||
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Prolactin increase may further inhibit libido. | |||||||||||||||
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Significant increases in serum prolactin levels were seen after all dynorphin doses; however, these were not dose-related. | |||||||||||||||
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Thioridazine was found to increase the serum prolactin level as well as the tumor size of a prolactin--secreting pituitary chromophobe adenoma in a schizophrenic man. | |||||||||||||||
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This case report highlights the importance of careful neuroleptic usage in patients in whom elevated prolactin levels are of concern and discusses alternative methods of treating psychosis when antidopaminergic medications are contraindicated. | |||||||||||||||
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Mean basal levels of PRL were significantly elevated in nursing women (P less than 0.01) compared to those in nonlactating postpartum women and women with galactorrhea. | |||||||||||||||
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D-fenfluramine test significantly increased PRL and cortisol plasma levels and Clonidine test induced a significant rise in GH values. | |||||||||||||||
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Patients given human menopausal gonadotropin and clomiphene citrate had significantly higher levels of plasma PRL compared to those given clomiphene only. | |||||||||||||||
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Several uncontrolled studies assessed prolactin rise during SSRI treatment, though only paroxetine-treated patients exhibited statistically significant elevations, while all subjects on fluoxetine, sertraline or venlafaxine showed not significant elevations of basal prolactin (Urban and Veldhuis 1991; Spigset and Mjorndal 1997; Cowen and Sargent 1997). | |||||||||||||||
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However, it has not been entirely clarified whether the serotoninergic or the dopaminergic system is especially accountable for the buspirone-induced prolactin secretive response (Maskall et al 1995) (Figure 2). | |||||||||||||||
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However, since the prolactin secretory pattern of drug-free psychiatric patients, measured throughout the day, is not different from that observed in healthy control subjects, the elevation of baseline prolactin in treated psychiatric patients seems to be more related to drug effects rather than to the illness itself (Haddad and Wieck 2004). | |||||||||||||||
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Among those, sertraline appears to be the most frequent cause of sustained hyperprolactinemia, but also fluoxetine and paroxetine may induce pathologic and symptomatic increases in prolactin levels. | |||||||||||||||
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Amisulpride-induced hyperprolactinemia is reported after both acute and chronic treatment and does not seem to be strongly dose-related: samples taken during the first eight hours following 20 or 100 mg i.v. single administration in ten healthy subjects revealed a significant elevation of prolactin levels (810 fold above baseline) (Wetzel et al 1994). | |||||||||||||||
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Several drugs may determine a significant increase in prolactin serum concentration that is frequently associated with symptoms. | |||||||||||||||
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