INT91519

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.52
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
IEC-6 2
enterocytes 2
esophageal epithelium 2
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 54 100.00 Very High Very High Very High
qutenza 27 100.00 Very High Very High Very High
Inflammation 107 99.60 Very High Very High Very High
antagonist 36 99.08 Very High Very High Very High
tetrodotoxin 6 97.28 Very High Very High Very High
Inflammatory mediators 30 95.20 Very High Very High Very High
calcitonin gene related peptide 32 82.96 Quite High
chemokine 18 82.12 Quite High
Inflammatory response 4 74.44 Quite High
Neurotransmitter 2 57.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 126 99.60 Very High Very High Very High
Gastroesophageal Reflux Disease 24 96.16 Very High Very High Very High
Esophageal Disease 44 95.68 Very High Very High Very High
Leukemia 1 88.64 High High
Neonatal Necrotizing Enterocolitis 68 76.04 Quite High
Necrosis 2 75.72 Quite High
Injury 30 68.32 Quite High
Infection 2 67.64 Quite High
Hypoxia 4 67.20 Quite High
Ganglion Cysts 2 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the PAF-stimulated cytosolic Ca2+ increase, capsaicin inhibited in particular the sustained portion of the raised Ca2+ level without attenuation of the peak height.
Negative_regulation (inhibited) of Positive_regulation (increase) of PAF-stimulated associated with qutenza
1) Confidence 0.41 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11034409 Disease Relevance 0.17 Pain Relevance 0.91
PAF caused a translocation of STAT3 from the cytosol to the nuclei of enterocytes and the PAF-induced induction of TLR4 expression was inhibited by pharmacological inhibition of the STAT3 and NFkB signaling pathways.


Negative_regulation (inhibited) of Positive_regulation (induction) of PAF-induced in enterocytes
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.69 Pain Relevance 0.14
To further address the potential mechanism of PAF-induced TLR4 upregulation, we pretreated IEC-6 cells with inhibitors of STAT3 and NF-?
Negative_regulation (mechanism) of Positive_regulation (upregulation) of PAF-induced in IEC-6
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Negative_regulation (inhibition) of Positive_regulation (activation) of PAF associated with inflammation and substance p
4) Confidence 0.31 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.65
The HCl-induced increase in PAF was abolished by the TRPV1 receptor antagonist IRTX but not by neural block with tetrodotoxin, indicating that production of PAF may arise from non-neural pathways, and most likely from the esophageal epithelium.
Neg (not) Negative_regulation (abolished) of Positive_regulation (increase) of PAF in esophageal epithelium associated with tetrodotoxin and antagonist
5) Confidence 0.31 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.07 Pain Relevance 0.45

General Comments

This test has worked.

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