INT91520

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Context Info
Confidence 0.30
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.99
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
neurons 2
endothelium 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 15 99.84 Very High Very High Very High
narcan 11 99.84 Very High Very High Very High
Kinase C 25 99.70 Very High Very High Very High
Morphine 27 99.32 Very High Very High Very High
bradykinin 66 93.04 High High
antagonist 18 90.96 High High
Opioid 28 87.40 High High
GABA receptor 1 78.56 Quite High
GABAergic 6 76.32 Quite High
Dopamine 2 75.72 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 6 94.40 High High
Breast Cancer 4 88.88 High High
Targeted Disruption 9 83.16 Quite High
Hypertension 49 79.68 Quite High
INFLAMMATION 12 68.88 Quite High
Leukemia 3 67.60 Quite High
Cardiovascular Disease 9 57.44 Quite High
Aging 1 55.88 Quite High
Glioma 13 50.00 Quite Low
Diabetes Mellitus 7 43.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Store-operated Ca2+ entry (SOCE) induced by thapsigargin was inhibited by capsaicin in a concentration-dependent manner.
Negative_regulation (inhibited) of Positive_regulation (induced) of Ca2 associated with qutenza
1) Confidence 0.30 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11034409 Disease Relevance 0.19 Pain Relevance 1.23
M) completely abolishes the transient increase in [Ca2+]i evoked by the Echinacea-extract (Figure 5B), consistent with the role of the IP3 receptor in mediating bioactivity.
Negative_regulation (abolishes) of Positive_regulation (increase) of Ca2
2) Confidence 0.26 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.08
Consistent with those previous studies, pre-incubation with SIN-1 specifically impaired U46619-induced [Ca2+]i mobilization in HEK.TP?
Negative_regulation (impaired) of Positive_regulation (incubation) of Ca2
3) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
These results indicate that activation of PKC significantly inhibits ATP mediated Ca2+ signaling and reduces resensitization of the response to ATP.
Negative_regulation (inhibits) of Positive_regulation (mediated) of Ca2 associated with kinase c
4) Confidence 0.17 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.44
In BE2C cells, stimulation of MOR1K with morphine produced a robust dose-dependent increase in Ca2+ levels that was blocked by naloxone.
Negative_regulation (blocked) of Positive_regulation (increase) of Ca2 associated with narcan and morphine
5) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.18 Pain Relevance 0.84
First, the increased [Ca2+]i oscillations by E2 was reproduced in GT1-1 neurons infected with an adenovirus expressing ER?
Negative_regulation (reproduced) of Positive_regulation (increased) of Ca2 in neurons
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0.17 Pain Relevance 0.27
Procedures that reduce the increase in endothelial Ca2+ concentration, such as the administration of vitamin D3, curtail the occurrence of endothelium-dependent contractions [42].
Negative_regulation (reduce) of Positive_regulation (increase) of Ca2 in endothelium
7) Confidence 0.03 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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