INT91527

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 38
Total Number 42
Disease Relevance 22.21
Pain Relevance 7.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSK) extracellular space (CTSK) lysosome (CTSK)
cytoplasm (CTSK)
Anatomy Link Frequency
osteoclasts 10
cartilage 3
joints 2
histiocyte 1
tendons 1
CTSK (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 618 99.84 Very High Very High Very High
rheumatoid arthritis 447 99.84 Very High Very High Very High
Inflammatory mediators 10 99.76 Very High Very High Very High
spinal inflammation 8 99.72 Very High Very High Very High
agonist 3 99.68 Very High Very High Very High
cytokine 99 98.20 Very High Very High Very High
antagonist 11 97.56 Very High Very High Very High
Inflammation 172 97.52 Very High Very High Very High
licofelone 48 97.00 Very High Very High Very High
Rheumatism 14 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 645 99.84 Very High Very High Very High
Rheumatoid Arthritis 447 99.84 Very High Very High Very High
Low Back Pain 8 99.72 Very High Very High Very High
Hypercalcemia 275 99.66 Very High Very High Very High
Necrosis 39 99.44 Very High Very High Very High
Tendinopathy 7 99.44 Very High Very High Very High
INFLAMMATION 197 99.36 Very High Very High Very High
Cancer 143 99.26 Very High Very High Very High
Foreign Bodies 6 98.36 Very High Very High Very High
Breast Cancer 93 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Involvement of multinucleated giant cells synthesizing cathepsin K in calcified tendinitis of the rotator cuff tendons.
Gene_expression (synthesizing) of cathepsin K in tendons associated with tendinopathy
1) Confidence 0.78 Published 2000 Journal Rheumatology (Oxford) Section Title Doc Link 11035125 Disease Relevance 0.29 Pain Relevance 0.10
Reverse transcription-polymerase chain reaction using human cathepsin K-specific oligonucleotide primers confirmed that synthesis of cathepsin K mRNA occurs in the tissues of calcified rotator cuffs.
Gene_expression (synthesis) of cathepsin K mRNA
2) Confidence 0.78 Published 2000 Journal Rheumatology (Oxford) Section Body Doc Link 11035125 Disease Relevance 0 Pain Relevance 0
Increased expression of cathepsin K around lymphocytic infiltrates in synovial tissue seems to facilitate the movement of mononuclear cells through the perivascular matrix [25]
Gene_expression (expression) of cathepsin K in mononuclear cells
3) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.66 Pain Relevance 0.14
Votta and colleagues demonstrated high levels of cathepsin K expression in osteoclasts at sites of extensive bone loss.
Gene_expression (expression) of cathepsin K in osteoclasts
4) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.65 Pain Relevance 0.12
and tumour necrosis factor alpha influence the expression of cathepsin K.
Gene_expression (expression) of cathepsin K associated with necrosis and cancer
5) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.72 Pain Relevance 0.13
The highest levels of cathepsin K were observed in patients with the highest Larsen scores.
Gene_expression (levels) of cathepsin K
6) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.20 Pain Relevance 0.08
Osteoprotegerin has been shown to inhibit the expression of cathepsin K, the main enzyme involved in bone resorption.
Gene_expression (expression) of cathepsin K associated with hypercalcemia
7) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 1.90 Pain Relevance 0.26
The blood examination at each visit consisted of the determination of cathepsin K, the erythrocyte sedimentation rate, the haemoglobin level, the thrombocyte count, the serum rheumatoid factor (RapiTex® RF; Dade Behring, Liederbach, Germany), antinuclear antibodies (indirect immunfluorescent technique, ANA Fluor Kit 240®; Diasorin, Stillwater, MN, USA) and C-reactive protein (CRP) (Rheumajet CRP®; Biokit, Barcelona, Spain).
Spec (determination) Gene_expression (determination) of cathepsin K in thrombocyte
8) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.77 Pain Relevance 0.37
To our knowledge, no study has previously investigated the serum levels of cathepsin K in RA.
Spec (investigated) Gene_expression (levels) of cathepsin K associated with rheumatoid arthritis
9) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.72 Pain Relevance 0.28
In normal synovium, cathepsin K expression was not increased and was restricted to fibroblast like cells [26,30-32].
Gene_expression (expression) of cathepsin K in synovium
10) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.54 Pain Relevance 0.20
Highly interesting is the expression of cathepsin K by fibroblasts and giant cells at sites of cartilage erosions.
Gene_expression (expression) of cathepsin K in fibroblasts
11) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.51 Pain Relevance 0.18
The overexpression of cathepsin K in RA synovia proves that this protease is responsible for the degradation of articular tissue in rheumatoid joints and in normal synovial tissue.
Gene_expression (overexpression) of cathepsin K in joints associated with rheumatoid arthritis
12) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.66 Pain Relevance 0.26
We found increased levels of cathepsin K compared with a healthy control group and found a significant correlation with radiological destruction, measured by the Larsen score.
Gene_expression (levels) of cathepsin K
13) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064888 Disease Relevance 0.63 Pain Relevance 0.17
and tumour necrosis factor alpha due to the increase of cathepsin K-expressing cells, proves this protease to be a valuable tool for bone research, and cathepsin K also may become a new and highly specific biomarker for RA [26].
Gene_expression (expressing) of cathepsin K associated with necrosis, cancer and rheumatoid arthritis
14) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.68 Pain Relevance 0.13
Serum levels of cathepsin K were measured in the sera of 100 patients suffering from RA according to the criteria of the American Rheumatism Association [17].
Gene_expression (levels) of cathepsin K associated with rheumatism and rheumatoid arthritis
15) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 1.79 Pain Relevance 0.44
Cathepsin K is essential for bone resorption, which depends on the production of cathepsin K by osteoclasts and its secretion into the extracellular department.
Gene_expression (production) of cathepsin K in osteoclasts associated with hypercalcemia
16) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.57 Pain Relevance 0.18
Serum MMP-3 and cathepsin K were assayed in duplicate using ELISA kits (Quantikine MMP-3, R&D Systems; and Cathepsin K, Biomedica).
Gene_expression (assayed) of Cathepsin K
17) Confidence 0.41 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0.08 Pain Relevance 0
Serum MMP-3 and cathepsin K were assayed in duplicate using ELISA kits (Quantikine MMP-3, R&D Systems; and Cathepsin K, Biomedica).
Gene_expression (assayed) of cathepsin K
18) Confidence 0.41 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0.08 Pain Relevance 0
OBJECTIVE: To measure serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis (AS) and in controls and to look for changes in these variables during TNFalpha antagonist therapy.
Gene_expression (levels) of cathepsin K associated with spinal inflammation and antagonist
19) Confidence 0.37 Published 2008 Journal Joint Bone Spine Section Abstract Doc Link 18674944 Disease Relevance 0.17 Pain Relevance 0.26
Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy.
Gene_expression (levels) of cathepsin K associated with spinal inflammation and antagonist
20) Confidence 0.37 Published 2008 Journal Joint Bone Spine Section Title Doc Link 18674944 Disease Relevance 0.10 Pain Relevance 0.29

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