INT91538

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Context Info
Confidence 0.11
First Reported 2000
Last Reported 2002
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 8
Disease Relevance 1.47
Pain Relevance 6.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
medulla 3
pons 3
spinal cord 1
Pomc (Mus musculus)
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 13 100.00 Very High Very High Very High
opioid receptor 86 99.80 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
medulla 32 99.64 Very High Very High Very High
Buprenorphine 9 99.06 Very High Very High Very High
Opioid 12 96.48 Very High Very High Very High
antagonist 13 94.76 High High
agonist 27 92.48 High High
Kappa opioid receptor 4 92.16 High High
Enkephalin 11 88.84 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 98.36 Very High Very High Very High
Sprains And Strains 24 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The G-protein activation induced by endogenous opioid peptide beta-endorphin in the spinal cord was significantly, but partially, attenuated by co-incubation with endomorphin-1 or endomorphin-2.
beta-endorphin Positive_regulation (activation) of G-protein in spinal cord associated with endogenous opioid and spinal cord
1) Confidence 0.11 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524159 Disease Relevance 0 Pain Relevance 0.45
The present results indicate that beta-endorphin activates G-protein by stimulation of putative epsilon-opioid receptors in the condition lacking the mu-opioid receptor, and buprenorphine acts as an antagonist for putative epsilon-opioid receptors in this condition.
beta-endorphin Positive_regulation (activates) of G-protein associated with antagonist, opioid receptor and buprenorphine
2) Confidence 0.10 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435410 Disease Relevance 0.32 Pain Relevance 1.08
Antagonistic property of buprenorphine for putative epsilon-opioid receptor-mediated G-protein activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse.
beta-endorphin Positive_regulation (activation) of G-protein in pons associated with targeted disruption, medulla, opioid receptor and buprenorphine
3) Confidence 0.06 Published 2002 Journal Neuroscience Section Title Doc Link 12435410 Disease Relevance 0.15 Pain Relevance 0.78
Differential involvement of mu(1)-opioid receptors in endomorphin- and beta-endorphin-induced G-protein activation in the mouse pons/medulla.
beta-endorphin Positive_regulation (activation) of G-protein in pons associated with medulla and opioid receptor
4) Confidence 0.04 Published 2000 Journal Neuroscience Section Title Doc Link 11036217 Disease Relevance 0.16 Pain Relevance 0.72
Moreover, beta-endorphin-induced G-protein activation in the mouse pons/medulla is, in part, mediated by mu(2)- and putative epsilon-, but not by mu(1)-opioid receptors.
beta-endorphin Positive_regulation (activation) of G-protein in medulla associated with medulla and opioid receptor
5) Confidence 0.04 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036217 Disease Relevance 0.26 Pain Relevance 0.85
Antagonistic property of buprenorphine for putative epsilon-opioid receptor-mediated G-protein activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse.
beta-endorphin Positive_regulation (activation) of G-protein in medulla associated with targeted disruption, medulla, opioid receptor and buprenorphine
6) Confidence 0.02 Published 2002 Journal Neuroscience Section Title Doc Link 12435410 Disease Relevance 0.15 Pain Relevance 0.78
Moreover, beta-endorphin-induced G-protein activation in the mouse pons/medulla is, in part, mediated by mu(2)- and putative epsilon-, but not by mu(1)-opioid receptors.
beta-endorphin Positive_regulation (activation) of G-protein in pons associated with medulla and opioid receptor
7) Confidence 0.01 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036217 Disease Relevance 0.26 Pain Relevance 0.85
Differential involvement of mu(1)-opioid receptors in endomorphin- and beta-endorphin-induced G-protein activation in the mouse pons/medulla.
beta-endorphin Positive_regulation (activation) of G-protein in medulla associated with medulla and opioid receptor
8) Confidence 0.01 Published 2000 Journal Neuroscience Section Title Doc Link 11036217 Disease Relevance 0.16 Pain Relevance 0.72

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