INT91539

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Context Info
Confidence 0.03
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.84
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc, Pomc) generation of precursor metabolites and energy (Pomc, Pomc) extracellular space (Pomc, Pomc)
extracellular region (Pomc, Pomc) cell-cell signaling (Pomc, Pomc) cytoplasm (Pomc, Pomc)
Anatomy Link Frequency
pons 4
medulla 4
Pomc (Mus musculus)
Pomc (Mus musculus)
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 40 99.58 Very High Very High Very High
medulla 20 99.24 Very High Very High Very High
Opioid 8 96.48 Very High Very High Very High
agonist 20 92.48 High High
Kappa opioid receptor 4 92.16 High High
Enkephalin 8 88.84 High High
Endogenous opioid 12 85.80 High High
mu opioid receptor 4 83.52 Quite High
antagonist 4 48.48 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 24 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential involvement of mu(1)-opioid receptors in endomorphin- and beta-endorphin-induced G-protein activation in the mouse pons/medulla.
beta-endorphin Positive_regulation (induced) of beta-endorphin Positive_regulation (activation) of G-protein in pons associated with medulla and opioid receptor
1) Confidence 0.03 Published 2000 Journal Neuroscience Section Title Doc Link 11036217 Disease Relevance 0.16 Pain Relevance 0.72
Moreover, beta-endorphin-induced G-protein activation in the mouse pons/medulla is, in part, mediated by mu(2)- and putative epsilon-, but not by mu(1)-opioid receptors.
beta-endorphin Positive_regulation (induced) of beta-endorphin Positive_regulation (activation) of G-protein in medulla associated with medulla and opioid receptor
2) Confidence 0.03 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036217 Disease Relevance 0.26 Pain Relevance 0.85
Differential involvement of mu(1)-opioid receptors in endomorphin- and beta-endorphin-induced G-protein activation in the mouse pons/medulla.
beta-endorphin Positive_regulation (induced) of beta-endorphin in medulla Positive_regulation (activation) of G-protein in pons associated with medulla and opioid receptor
3) Confidence 0.01 Published 2000 Journal Neuroscience Section Title Doc Link 11036217 Disease Relevance 0.16 Pain Relevance 0.72
Moreover, beta-endorphin-induced G-protein activation in the mouse pons/medulla is, in part, mediated by mu(2)- and putative epsilon-, but not by mu(1)-opioid receptors.
beta-endorphin Positive_regulation (induced) of beta-endorphin in pons Positive_regulation (activation) of G-protein in medulla associated with medulla and opioid receptor
4) Confidence 0.01 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036217 Disease Relevance 0.26 Pain Relevance 0.85

General Comments

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