INT91545

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Context Info
Confidence 0.01
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B, CALCRL) signal transducer activity (HTR1B, CALCRL) protein transporter activity (CALCRL)
endosome (CALCRL) endoplasmic reticulum (CALCRL) lysosome (CALCRL)
HTR1B (Homo sapiens)
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 4 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Potency 2 100.00 Very High Very High Very High
antagonist 1 91.12 High High
Migraine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Glioma 1 87.32 High High
Increased Venous Pressure Under Development 1 25.00 Low Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In competition experiments with 1 nM [3H]5-CT, the following 5-HT receptor ligands exhibited a higher affinity for the mutant receptor than for the WTR: L-694,247, 5-CT, 5-HT, sumatriptan (agonists listed at decreasing order of potency) and SB-224289 (a selective h5-HT1B receptor inverse agonist with competitive antagonistic properties).
5-HT1B Binding (affinity) of receptor associated with sumatriptan, agonist and potency
1) Confidence 0.01 Published 2000 Journal Pharmacogenetics Section Abstract Doc Link 11037806 Disease Relevance 0.09 Pain Relevance 0.41

General Comments

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