INT9155

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Context Info
Confidence 0.77
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 60
Total Number 63
Disease Relevance 17.97
Pain Relevance 23.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
striatum 6
astrocytes 4
Leydig cells 3
spinal 2
neurons 2
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 341 100.00 Very High Very High Very High
gABA 315 100.00 Very High Very High Very High
Enkephalin 38 100.00 Very High Very High Very High
Spinal cord 28 100.00 Very High Very High Very High
monoamine 10 100.00 Very High Very High Very High
Deafferentation 6 99.92 Very High Very High Very High
Morphine 209 99.84 Very High Very High Very High
dexamethasone 6 99.78 Very High Very High Very High
narcan 140 99.74 Very High Very High Very High
Clonidine 12 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 5 99.96 Very High Very High Very High
Generalized Anxiety Disorder 82 99.92 Very High Very High Very High
Catalepsy 24 99.92 Very High Very High Very High
Frailty 4 99.88 Very High Very High Very High
Diabetes Mellitus 216 99.82 Very High Very High Very High
End Stage Liver Disease 4 99.40 Very High Very High Very High
Stress 313 98.92 Very High Very High Very High
Cancer 110 98.92 Very High Very High Very High
Necrosis 16 98.68 Very High Very High Very High
Encephalopathy 4 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our goal was to evaluate the expression of glutamine synthetase and its complementary miRNA in blood microvesicles and gut tissues of IBS patients with increased intestinal membrane permeability.
Gene_expression (expression) of glutamine synthetase in gut associated with spastic colon
1) Confidence 0.77 Published 2010 Journal Gut Section Abstract Doc Link 19951903 Disease Relevance 0.17 Pain Relevance 0.36
To further confirm the relationship between miRNA and glutamine synthetase expression, cell culture experiments were conducted.
Gene_expression (expression) of glutamine synthetase
2) Confidence 0.77 Published 2010 Journal Gut Section Body Doc Link 19951903 Disease Relevance 0 Pain Relevance 0
RESULTS: A subset of patients with IBS (8/19, 42%) had increased intestinal membrane permeability and decreased glutamine synthetase expression compared to patients with IBS normal membrane permeability, and to controls.
Gene_expression (expression) of glutamine synthetase
3) Confidence 0.77 Published 2010 Journal Gut Section Body Doc Link 19951903 Disease Relevance 0 Pain Relevance 0
The fact that changes in glutamine synthetase expression were linked to morphine administration by three different methods (isotope-coded affinity tags, (ICAT), 2D gel electrophoresis and Western blot) in four distinct laboratories seems very appealing: It indicates that quantitative changes occur in this enzyme during morphine uptake.
Gene_expression (expression) of glutamine synthetase associated with morphine
4) Confidence 0.76 Published 2010 Journal Anal Bioanal Chem Section Body Doc Link PMC2990007 Disease Relevance 0.11 Pain Relevance 0.65
In this paper, we have proven that despite the fact that several previous proteome/morphinome studies have indicated changes in glutamine synthetase expression or quantity in cells/tissues/organisms, we did not observe any significant changes in enzyme activity during our experiments.
Gene_expression (expression) of glutamine synthetase
5) Confidence 0.76 Published 2010 Journal Anal Bioanal Chem Section Body Doc Link PMC2990007 Disease Relevance 0 Pain Relevance 0.21
We further examined the effect of intrathecal dexamethasone infusion on the development of morphine tolerance and on expression of the intracellular glutamate metabolizing enzymes, glutamate dehydrogenase and glutamine synthetase, in the spinal cord.
Gene_expression (expression) of glutamine synthetase in spinal cord associated with glutamate, tolerance, dexamethasone, spinal cord, morphine and intrathecal
6) Confidence 0.74 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17312234 Disease Relevance 0 Pain Relevance 1.13
The effect of dexamethasone on spinal glutamine synthetase and glutamate dehydrogenase expression in morphine-tolerant rats.
Gene_expression (expression) of glutamine synthetase in spinal associated with glutamate, dexamethasone and morphine
7) Confidence 0.74 Published 2007 Journal Anesth. Analg. Section Title Doc Link 17312234 Disease Relevance 0 Pain Relevance 1.13
We studied in vitro the effects of anticonvulsant drugs Gabapentin and Topiramate on the production of reactive oxygen species and nitric oxide (NO), the activity of glutamine synthetase (GS), and cell viability in primary cultures of rat cortical astrocytes which are intimately involved in the normal functioning of neurons.
Gene_expression (production) of GS in astrocytes associated with anticonvulsant and gabapentin
8) Confidence 0.68 Published 2001 Journal Neuroreport Section Abstract Doc Link 11409743 Disease Relevance 0.07 Pain Relevance 0.30
We studied in vitro the effects of anticonvulsant drugs Gabapentin and Topiramate on the production of reactive oxygen species and nitric oxide (NO), the activity of glutamine synthetase (GS), and cell viability in primary cultures of rat cortical astrocytes which are intimately involved in the normal functioning of neurons.
Gene_expression (production) of glutamine synthetase in astrocytes associated with anticonvulsant and gabapentin
9) Confidence 0.68 Published 2001 Journal Neuroreport Section Abstract Doc Link 11409743 Disease Relevance 0.07 Pain Relevance 0.30
The contribution of the stimulatory guanine nucleotide regulatory protein (Gs) to prostaglandin E2 (PGE2)-induced hyperalgesia was investigated in the hairy skin of the rat hindpaw using the Randall-Selitto paw-withdrawal test.
Spec (investigated) Gene_expression (contribution) of Gs in PGE2 associated with hyperalgesia and withdrawal
10) Confidence 0.65 Published 1989 Journal Brain Res. Section Abstract Doc Link 2502301 Disease Relevance 0.32 Pain Relevance 0.38
In addition to these five genes, we have defined the “greater urea cycle” and also examined the expression of mRNA for nine additional enzymes that play a role in the disposal of nitrogen in the liver (glutamine synthetase, glutamine dehydrogenase, malate dehydrogenase, carbonic anhydrase, glutaminase, ornithine decarboxylase, tyrosine aminotransferase, aspartate aminotransferase and alanine aminotransferase), and two additional genes involved in transcriptional regulation of those genes; glucocorticoid receptor (GR) and CCAAT/enhancer binding protein (CEBP-?).
Spec (examined) Gene_expression (expression) of glutamine synthetase in liver
11) Confidence 0.58 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.29 Pain Relevance 0.06
Cannabidiol prevents diabetes-induced glutamine synthetase nitration and restores its activity
Gene_expression (nitration) of glutamine synthetase associated with diabetes mellitus
12) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925907 Disease Relevance 1.03 Pain Relevance 0.04
AIM: To explore the role of clonidine (Clo) on myocardial Gs alpha mRNA expression after scalds in rats.
Gene_expression (expression) of Gs alpha mRNA associated with clonidine
13) Confidence 0.54 Published 2002 Journal Yao Xue Xue Bao Section Abstract Doc Link 12579893 Disease Relevance 0 Pain Relevance 0.17
Clo (0.3, 1.0 and 3.0 mg.kg-1, i.p.) was shown to increase myocardial Gs alpha mRNA expression level (P < 0.01 or P < 0.05) after scalds to (131 +/- 28)%, (142 +/- 51)% and (139 +/- 48)% of the scald group, respectively, which were correlated with the Clo dose (gamma = 0.597, P < 0.05).
Gene_expression (expression) of Gs alpha mRNA
14) Confidence 0.54 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12579893 Disease Relevance 0 Pain Relevance 0
The myocardial Gs alpha mRNA expression level, cyclic AMP content and adenylyl cyclase (AC) activity were determined with dot blotting hybridization, in situ hybridization, radioimmunoassay and indirect method.
Gene_expression (expression) of Gs alpha mRNA
15) Confidence 0.54 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12579893 Disease Relevance 0 Pain Relevance 0
[Effects of clonidine on myocardial Gs alpha mRNA expression after scalds in rats].
Gene_expression (expression) of Gs alpha mRNA associated with clonidine
16) Confidence 0.54 Published 2002 Journal Yao Xue Xue Bao Section Title Doc Link 12579893 Disease Relevance 0 Pain Relevance 0.20
In this study, we further characterized the alterations in cerebellar GABAergic transmission in these mutants by examining the expression of the messenger RNA encoding glutamate decarboxylase (67000 mol. wt) with in situ hybridization histochemistry at the single cell level in Purkinje cells and neurons of the deep cerebellar nuclei.
Gene_expression (expression) of glutamate decarboxylase in Purkinje cells associated with glutamate and gabaergic
17) Confidence 0.52 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466432 Disease Relevance 0.75 Pain Relevance 0.39
Differential expression of glutamate decarboxylase messenger RNA in cerebellar Purkinje cells and deep cerebellar nuclei of the genetically dystonic rat.
Gene_expression (expression) of glutamate decarboxylase in Purkinje cells associated with glutamate, dystonia and enkephalin
18) Confidence 0.52 Published 1998 Journal Neuroscience Section Title Doc Link 9466432 Disease Relevance 0.79 Pain Relevance 0.40
GS (2- micro M) caused spinal seizures in the rats after the SCI, and GS (6- micro M) produced seizures in the uninjured anesthetized rats.
Gene_expression (produced) of GS in spinal associated with convulsion and frailty
19) Confidence 0.51 Published 2003 Journal Yonsei Med. J. Section Abstract Doc Link 12619185 Disease Relevance 0.70 Pain Relevance 0.39
Further studies of human samples should provide clinical evidence and implications for GS nitration.
Gene_expression (nitration) of GS
20) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925907 Disease Relevance 0.71 Pain Relevance 0.22

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