INT91550

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Context Info
Confidence 0.10
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.68
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PPM1D) cell cycle (PPM1D)
Anatomy Link Frequency
bars 1
PPM1D (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 68 98.40 Very High Very High Very High
antagonist 77 93.56 High High
Opioid 28 93.08 High High
opioid receptor 40 87.20 High High
Morphine 68 81.12 Quite High
agonist 162 73.00 Quite High
Sumatriptan 4 72.88 Quite High
Potency 30 68.72 Quite High
mu opioid receptor 68 60.16 Quite High
anticonvulsant 1 49.96 Quite Low
Disease Link Frequency Relevance Heat
Glioma 1 99.72 Very High Very High Very High
Disease 51 91.20 High High
Muscle Disease 5 84.00 Quite High
Bordatella Infection 8 81.20 Quite High
Arrhythmias 2 Under Development 2 59.64 Quite High
Myocardial Infarction 1 58.08 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 53.68 Quite High
Deafness 5 51.88 Quite High
Diabetes Mellitus 7 51.36 Quite High
Convulsion 6 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, CTOP treatment increased both mutant (182 ± 4%) and wild type receptor (157 ± 20%) expression levels but failed to induce a significantly higher expression level for Ala348,353 hMOR as compared to the wild type receptor (Figure 4, see discussion).
Gene_expression (expression) of wild type receptor
1) Confidence 0.10 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC317294 Disease Relevance 0 Pain Relevance 0.58
Moreover, since the expression level of Ala348,353 hMOR was approximately three times lower than the wild-type receptor, these results strongly suggest that the mutant is a CAM receptor.
Gene_expression (expression) of wild-type receptor
2) Confidence 0.10 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC317294 Disease Relevance 0.08 Pain Relevance 0.10
Also the mutant receptor expression level following CTOP treatment was not significantly higher than the one observed for the wild-type receptor.
Gene_expression (expression) of wild-type receptor
3) Confidence 0.10 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC317294 Disease Relevance 0 Pain Relevance 0.27
On the other hand, CTOP treatment increased both mutant (182 ± 4%) and wild type receptor (157 ± 20%) expression levels but failed to induce a significantly higher expression level for Ala348,353 hMOR as compared to the wild type receptor (Figure 4, see discussion).
Gene_expression (expression) of wild type receptor
4) Confidence 0.08 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC317294 Disease Relevance 0 Pain Relevance 0.66
Stably transfected rat C6 glioma cells, which express either the h5-HT1B variant receptor (VR) or the wild-type receptor (WTR) were used.
Gene_expression (express) of wild-type receptor associated with glioma
5) Confidence 0.04 Published 2000 Journal Pharmacogenetics Section Abstract Doc Link 11037806 Disease Relevance 0.10 Pain Relevance 0.20
While increasing the amount of the wild-type receptor caused a dose dependent increase in transcriptional activity (Figure 5B, open bars), the addition of increasing amounts of Y355X PPAR?
Gene_expression (amount) of wild-type receptor in bars
6) Confidence 0.03 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0 Pain Relevance 0
To complement mtDNA protein defects it is possible to express the wild-type protein allotopically from nuclear transfected constructs.
Gene_expression (express) of wild-type protein
7) Confidence 0.01 Published 2010 Journal Biochim Biophys Acta Section Body Doc Link PMC2795853 Disease Relevance 0.50 Pain Relevance 0

General Comments

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