INT91553

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2007
Negated 1
Speculated 2
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
neurons 4
Dbi (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
antagonist 7 99.78 Very High Very High Very High
opioid receptor 1 99.54 Very High Very High Very High
Nicotine 20 98.52 Very High Very High Very High
narcan 2 93.32 High High
mu opioid receptor 3 87.72 High High
Delta opioid receptors 1 77.44 Quite High
Calcium channel 2 75.00 Quite High
tetrodotoxin 2 72.80 Quite High
local anesthetic 2 67.52 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the mechanisms underlying the increase in diazepam binding inhibitor (DBI) and its mRNA expression induced by nicotine (0.1 microM) exposure for 24 h using mouse cerebral cortical neurons in primary culture.
Spec (investigated) Regulation (underlying) of Spec (investigated) Positive_regulation (increase) of DBI in neurons associated with nicotine
1) Confidence 0.44 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.47
We investigated the mechanisms underlying the increase in diazepam binding inhibitor (DBI) and its mRNA expression induced by nicotine (0.1 microM) exposure for 24 h using mouse cerebral cortical neurons in primary culture.
Spec (investigated) Regulation (underlying) of Spec (investigated) Positive_regulation (increase) of diazepam binding inhibitor in neurons associated with nicotine
2) Confidence 0.44 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.47
On the other hand, kappa- and delta-opioid receptor antagonists showed no effects on the morphine-induced increase in DBI mRNA.
Neg (no) Regulation (effects) of Positive_regulation (increase) of DBI mRNA associated with antagonist, opioid receptor and morphine
3) Confidence 0.24 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 1.06

General Comments

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