INT91554

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.77
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
cerebral cortex 4
brain 2
Dbi (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 18 99.78 Very High Very High Very High
Nicotine 12 99.64 Very High Very High Very High
cerebral cortex 2 99.60 Very High Very High Very High
alcohol 1 99.06 Very High Very High Very High
Calcium channel 1 97.64 Very High Very High Very High
withdrawal 4 95.56 Very High Very High Very High
addiction 6 94.80 High High
Neuropeptide 1 92.36 High High
antagonist 9 85.84 High High
opioid receptor 3 82.16 Quite High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 1 95.92 Very High Very High Very High
Drug Dependence 6 94.80 High High
Anxiety Disorder 2 93.52 High High
Opiate Addiction 3 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When we examined brain from mice dependent on alcohol, nicotine, and morphine, we observed that the levels of DBI protein and its mRNA significantly increased.
Positive_regulation (increased) of Transcription (levels) of DBI protein in brain associated with nicotine, morphine and alcohol
1) Confidence 0.50 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.77 Pain Relevance 0.76
Mechanism for increase in expression of cerebral diazepam binding inhibitor mRNA by nicotine: involvement of L-type voltage-dependent calcium channels.
Positive_regulation (increase) of Transcription (expression) of diazepam binding inhibitor associated with calcium channel and nicotine
2) Confidence 0.45 Published 2000 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.65
Our previous in vivo experiment demonstrates that chronic morphine treatment up-regulates diazepam binding inhibitor (DBI) transcripts in mouse cerebral cortex, although detailed mechanisms were unclear (Katsura et al. [1998] J.
Positive_regulation (up-regulates) of Transcription (transcripts) of diazepam binding inhibitor in cerebral cortex associated with cerebral cortex and morphine
3) Confidence 0.44 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.47
Our previous in vivo experiment demonstrates that chronic morphine treatment up-regulates diazepam binding inhibitor (DBI) transcripts in mouse cerebral cortex, although detailed mechanisms were unclear (Katsura et al. [1998] J.
Positive_regulation (up-regulates) of Transcription (transcripts) of DBI in cerebral cortex associated with cerebral cortex and morphine
4) Confidence 0.44 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.47

General Comments

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