INT91560

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.62
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
globus pallidus 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 13 100.00 Very High Very High Very High
agonist 2 98.56 Very High Very High Very High
substance P 4 93.76 High High
Substantia nigra 2 90.92 High High
Eae 4 86.56 High High
Serotonin 4 80.68 Quite High
Opioid 2 79.52 Quite High
antagonist 2 78.96 Quite High
Neuropeptide 1 78.40 Quite High
narcan 2 78.08 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 98.36 Very High Very High Very High
Obesity 2 97.56 Very High Very High Very High
Body Weight 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene results in a loss of CPE activity that correlates with the development of late onset obesity (Nagert, J.
Positive_regulation (results) of Negative_regulation (loss) of CPE associated with obesity
1) Confidence 0.40 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11038363 Disease Relevance 0.10 Pain Relevance 0.04
Our results demonstrate that MDMA induces a decrease in pallidal met-enkephalin immunolabelling in wild-type, but not in 5-HT1B receptor knockout mice.
Positive_regulation (induces) of Negative_regulation (decrease) of met-enkephalin associated with targeted disruption and enkephalin
2) Confidence 0.10 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887420 Disease Relevance 0.26 Pain Relevance 0.74
Similar results were obtained following treatment with the 5-HT1A/1B agonist RU24969 (5 mg/kg, 3 h), suggesting that activation of 5-HT1B receptors leads to a reduction in met-enkephalin levels in the globus pallidus.
Positive_regulation (leads) of Negative_regulation (reduction) of met-enkephalin in globus pallidus associated with agonist and enkephalin
3) Confidence 0.09 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887420 Disease Relevance 0.27 Pain Relevance 0.88

General Comments

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