INT9157

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 2.30
Pain Relevance 9.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
brain 4
adrenal medulla 2
astrocytes 2
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 50 100.00 Very High Very High Very High
Morphine 17 100.00 Very High Very High Very High
medulla 10 100.00 Very High Very High Very High
narcan 26 99.98 Very High Very High Very High
analgesia 8 99.92 Very High Very High Very High
addiction 3 99.78 Very High Very High Very High
tolerance 4 99.48 Very High Very High Very High
Pain 2 98.76 Very High Very High Very High
dexamethasone 1 97.04 Very High Very High Very High
opioid receptor 5 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 6 99.24 Very High Very High Very High
Cancer 6 99.06 Very High Very High Very High
Aids-related Complex 7 92.24 High High
Hyperalgesia 2 88.12 High High
Body Weight 4 88.08 High High
Nociception 1 76.04 Quite High
Depression 1 75.00 Quite High
Sleep Disorders 3 70.72 Quite High
Syndrome 1 56.32 Quite High
Drug Dependence 1 53.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same treatment produced, in adrenal medulla, a shift from higher molecular weight to lower molecular weight enkephalin-containing peptides, an increase of enkephalin peptides, and a decrease of proenkephalin mRNA content.
Negative_regulation (produced) of Negative_regulation (decrease) of proenkephalin mRNA in adrenal medulla associated with medulla and enkephalin
1) Confidence 0.43 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 4078631 Disease Relevance 0 Pain Relevance 1.21
Naloxone applied at iontophoretic current that blocked the inhibitory effect of [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin, reduced the peak inhibitory effect of endomorphins on the NMDA- and natural stimulus-evoked responses.
Negative_regulation (blocked) of Negative_regulation (effect) of enkephalin associated with narcan and enkephalin
2) Confidence 0.42 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10848572 Disease Relevance 0.08 Pain Relevance 0.35
Low doses of naloxone produce analgesia in the mouse brain by blocking presynaptic autoinhibition of enkephalin release.
Negative_regulation (blocking) of Negative_regulation (autoinhibition) of enkephalin in brain associated with narcan, enkephalin and analgesia
3) Confidence 0.41 Published 1986 Journal Neurosci. Lett. Section Title Doc Link 3714107 Disease Relevance 0.09 Pain Relevance 1.34
These findings strongly suggest that in the mouse brain a very low dose of naloxone produces analgesia by blocking autoinhibition of enkephalin release.
Negative_regulation (blocking) of Negative_regulation (autoinhibition) of enkephalin in brain associated with narcan, enkephalin and analgesia
4) Confidence 0.41 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3714107 Disease Relevance 0.08 Pain Relevance 1.14
Thus, naloxone prevented the inhibitory effect of Met-Enk on Ach-stimulated CA release.
Negative_regulation (prevented) of Negative_regulation (effect) of Met-Enk associated with narcan
5) Confidence 0.40 Published 1989 Journal Endocrinology Section Abstract Doc Link 2752969 Disease Relevance 0 Pain Relevance 0.74
Messenger RNA levels of ProDynorphin (proDYN), but not pro-opiomelanocortin (POMC) nor proEnkephalin (proENK) were significantly decreased 2 h after 2-DG injection.
Negative_regulation (decreased) of Negative_regulation (decreased) of proEnkephalin
6) Confidence 0.39 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593862 Disease Relevance 0.17 Pain Relevance 0.23
Messenger RNA levels of ProDynorphin (proDYN), but not pro-opiomelanocortin (POMC) nor proEnkephalin (proENK) were significantly decreased 2 h after 2-DG injection.
Negative_regulation (decreased) of Negative_regulation (levels) of proENK
7) Confidence 0.39 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593862 Disease Relevance 0.17 Pain Relevance 0.23
Lowered serum glucocorticoid levels as a consequence of bilateral adrenalectomy resulted in a reduction of ganglionic L-Enk content that was reversed by exposure of adrenalectomized animals to the synthetic glucocorticoid, dexamethasone.
Negative_regulation (reversed) of Negative_regulation (reduction) of L-Enk associated with dexamethasone
8) Confidence 0.38 Published 1993 Journal J. Neurobiol. Section Abstract Doc Link 8409981 Disease Relevance 0 Pain Relevance 0.50
These results suggest that diazepam inhibits morphine tolerance and dependence, and also prevents morphine-induced decrease in the CNS Met-enkephalin levels in morphine dependent rats.
Negative_regulation (prevents) of Negative_regulation (decrease) of Met-enkephalin associated with addiction, tolerance, enkephalin and morphine
9) Confidence 0.37 Published 1994 Journal Brain Res. Section Abstract Doc Link 8062072 Disease Relevance 0.30 Pain Relevance 1.98
Tumor necrosis factor-alpha treatment was unable to reverse the inhibitory effect of gamma-interferon pretreatment on proenkephalin messenger RNA levels in the astrocytes.
Neg (unable) Negative_regulation (reverse) of Negative_regulation (effect) of proenkephalin in astrocytes associated with necrosis and cancer
10) Confidence 0.32 Published 1992 Journal Endocrinology Section Abstract Doc Link 1396335 Disease Relevance 0.95 Pain Relevance 0.30
Subcutaneous administration of bromocriptine to suckled dams markedly suppressed circulating PRL levels and decreased preproenkephalin mRNA signal levels to 38 and 50% of control levels in the arcuate and ventromedial nuclei, respectively.
Negative_regulation (suppressed) of Negative_regulation (decreased) of preproenkephalin mRNA
11) Confidence 0.22 Published 2003 Journal Endocrine Section Abstract Doc Link 12668876 Disease Relevance 0.37 Pain Relevance 0
Atropine (1 microM) blocked the inhibitory effect of physostigmine on the depressant action of D-Pen2,L-Pen5-enkephalin.
Negative_regulation (blocked) of Negative_regulation (effect) of L-Pen5-enkephalin associated with enkephalin
12) Confidence 0.16 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2852536 Disease Relevance 0.07 Pain Relevance 0.81
Dithiothreitol prevents the inhibition of enkephalin conversion produced by p-chloromecurobenzoate.
Negative_regulation (prevents) of Negative_regulation (inhibition) of enkephalin associated with enkephalin
13) Confidence 0.05 Published 1982 Journal Life Sci. Section Abstract Doc Link 7154831 Disease Relevance 0 Pain Relevance 0.70

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