INT91575

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Context Info
Confidence 0.02
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.23
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 96 100.00 Very High Very High Very High
agonist 77 100.00 Very High Very High Very High
Opioid 15 98.16 Very High Very High Very High
addiction 6 98.12 Very High Very High Very High
tolerance 7 97.52 Very High Very High Very High
analgesia 1 95.48 Very High Very High Very High
Immobilon 7 90.76 High High
psychological dependence 1 88.40 High High
Morphine 2 65.72 Quite High
Enkephalin 1 32.16 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 88.40 High High
Neuroblastoma 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results represent the identification of the GRK phosphorylation site on an opioid receptor for the first time and demonstrate that GRK is the prominent kinase responsible for agonist-induced opioid receptor phosphorylation in vivo.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor
1) Confidence 0.02 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.51
Taken together, we have demonstrated that agonist-induced opioid receptor phosphorylation occurs exclusively at two phosphate acceptor sites (T358 and S363) of GRK2 at the DOR carboxyl terminus.
Positive_regulation (occurs) of Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor
2) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.70
Taken together, we have demonstrated that agonist-induced opioid receptor phosphorylation occurs exclusively at two phosphate acceptor sites (T358 and S363) of GRK2 at the DOR carboxyl terminus.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor
3) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.70
Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation.
Positive_regulation (responsible) of Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor
4) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Title Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.95
Our previous research suggested that agonist-induced delta-opioid receptor (DOR) phosphorylation occurs at the receptor carboxyl terminal domain.
Positive_regulation (occurs) of Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor
5) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.83
Our previous research suggested that agonist-induced delta-opioid receptor (DOR) phosphorylation occurs at the receptor carboxyl terminal domain.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor
6) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.83
The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment.
Positive_regulation (role) of Phosphorylation (phosphorylation) of opioid receptor associated with opioid receptor and opioid
7) Confidence 0.01 Published 2005 Journal Neurosignals Section Title Doc Link 16772732 Disease Relevance 0.09 Pain Relevance 0.91
While all agonists were potent to increase phosphorylation of opioid receptor, we showed no impairment of receptor phosphorylation level after PKC inhibitor pretreatment.
Positive_regulation (increase) of Phosphorylation (hosphorylation ) of opioid receptor associated with agonist and opioid receptor
8) Confidence 0.01 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18395423 Disease Relevance 0.14 Pain Relevance 0.64

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