INT9158

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 9
Speculated 45
Reported most in Abstract
Documents 722
Total Number 767
Disease Relevance 522.01
Pain Relevance 277.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
macrophages 40
plasma 32
spinal cord 27
blood 22
brain 19
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2930 100.00 Very High Very High Very High
cytokine 2505 100.00 Very High Very High Very High
Pain 792 100.00 Very High Very High Very High
Glutamate 387 100.00 Very High Very High Very High
Inflammatory mediators 384 100.00 Very High Very High Very High
Spinal cord 328 100.00 Very High Very High Very High
Nerve growth factor 289 100.00 Very High Very High Very High
Hyperalgesia 283 100.00 Very High Very High Very High
COX2 205 100.00 Very High Very High Very High
rheumatoid arthritis 205 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3545 100.00 Very High Very High Very High
Cancer 1290 100.00 Very High Very High Very High
Necrosis 872 100.00 Very High Very High Very High
Pain 627 100.00 Very High Very High Very High
Hyperalgesia 495 100.00 Very High Very High Very High
Adhesions 424 100.00 Very High Very High Very High
Rheumatoid Arthritis 252 100.00 Very High Very High Very High
Ganglion Cysts 217 100.00 Very High Very High Very High
Emergencies 36 100.00 Very High Very High Very High
Neuropathic Pain 1307 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, LPS-stimulated tumor necrosis factor-alpha and nitric oxide production decreased 50 and 60%, respectively.
Gene_expression (production) of tumor necrosis factor-alpha associated with necrosis and cancer
1) Confidence 0.78 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9227482 Disease Relevance 0.57 Pain Relevance 0.10
The authors of this study investigated pain-related behaviors and expression of tumor necrosis factor-alpha (TNF-alpha) in the dorsal root ganglion (DRG) to evaluate the effects of punctured NP on lumbar radiculopathy.
Gene_expression (expression) of tumor necrosis factor-alpha in DRG associated with ganglion cysts, dorsal root ganglion, pain, necrosis, cancer and sciatica
2) Confidence 0.78 Published 2009 Journal J Neurosurg Spine Section Abstract Doc Link 19929348 Disease Relevance 0.85 Pain Relevance 0.51
OBJECTIVE: To investigate the expression of tumor necrosis factor-alpha (TNF-alpha) in lungs following coronary artery occlusion (CAO) and the effect of morphine pretreatment via epidural administration on its expression in the rats.
Spec (investigate) Gene_expression (expression) of tumor necrosis factor-alpha in lungs associated with necrosis, cancer, epidural and morphine
3) Confidence 0.78 Published 2008 Journal Zhongguo Wei Zhong Bing Ji Jiu Yi Xue Section Abstract Doc Link 19111113 Disease Relevance 0.42 Pain Relevance 0.26
[Effects of epidurally administration of morphine at thoracic level on expression of tumor necrosis factor-alpha in the lungs in acute myocardial ischemia in rats].
Gene_expression (expression) of tumor necrosis factor-alpha in lungs associated with necrosis, coronary artery disease, cancer, ischemia and morphine
4) Confidence 0.78 Published 2008 Journal Zhongguo Wei Zhong Bing Ji Jiu Yi Xue Section Title Doc Link 19111113 Disease Relevance 0.49 Pain Relevance 0.29
The expression of TNF-alpha in lungs was assessed with immuno- histochemistry and enzyme linked immunosorbent assay (ELISA).
Gene_expression (expression) of TNF-alpha in lungs
5) Confidence 0.78 Published 2008 Journal Zhongguo Wei Zhong Bing Ji Jiu Yi Xue Section Body Doc Link 19111113 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate the expression of tumor necrosis factor-alpha (TNF-alpha) in lungs following coronary artery occlusion (CAO) and the effect of morphine pretreatment via epidural administration on its expression in the rats.
Spec (investigate) Gene_expression (expression) of TNF-alpha in lungs associated with necrosis, cancer, epidural and morphine
6) Confidence 0.78 Published 2008 Journal Zhongguo Wei Zhong Bing Ji Jiu Yi Xue Section Abstract Doc Link 19111113 Disease Relevance 0.42 Pain Relevance 0.26
The authors of this study investigated pain-related behaviors and expression of tumor necrosis factor-alpha (TNF-alpha) in the dorsal root ganglion (DRG) to evaluate the effects of punctured NP on lumbar radiculopathy.
Spec (investigated) Gene_expression (expression) of TNF-alpha in DRG associated with ganglion cysts, dorsal root ganglion, pain, necrosis, cancer and sciatica
7) Confidence 0.78 Published 2009 Journal J Neurosurg Spine Section Abstract Doc Link 19929348 Disease Relevance 0.85 Pain Relevance 0.51
A significant increase in the expression of TNF-alpha-positive neurons in DRG specimens was observed in both NP graft groups.
Gene_expression (expression) of TNF-alpha in DRG
8) Confidence 0.78 Published 2009 Journal J Neurosurg Spine Section Body Doc Link 19929348 Disease Relevance 0.13 Pain Relevance 0
Tumor necrosis factor-alpha (TNFalpha) production, on the other hand, was decreased by 50%.
Gene_expression (production) of Tumor necrosis factor-alpha associated with necrosis and cancer
9) Confidence 0.78 Published 2001 Journal Shock Section Abstract Doc Link 11336202 Disease Relevance 0.50 Pain Relevance 0.12
Tumor necrosis factor-alpha (TNFalpha) production, on the other hand, was decreased by 50%.
Gene_expression (production) of TNFalpha associated with necrosis and cancer
10) Confidence 0.78 Published 2001 Journal Shock Section Abstract Doc Link 11336202 Disease Relevance 0.50 Pain Relevance 0.12
The present study employs a chronic constriction injury (CCI) model of neuropathic pain to examine TNFalpha production in the central nervous system (CNS) and in the periphery in this pain model.
Spec (examine) Gene_expression (production) of TNFalpha in CNS associated with pain, eae, injury, neuropathic pain and central nervous system
11) Confidence 0.78 Published 2002 Journal Reg Anesth Pain Med Section Abstract Doc Link 12132059 Disease Relevance 0.80 Pain Relevance 0.51
Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain.
Gene_expression (Expression) of tumor necrosis factor alpha in brain associated with pain, necrosis, cancer and lasting pain
12) Confidence 0.78 Published 2002 Journal Reg Anesth Pain Med Section Title Doc Link 12132059 Disease Relevance 0.67 Pain Relevance 0.61
The increase in TNFalpha expression is specific to discrete regions of the CNS, rather than being the result of a systemic inflammatory response, since TNFalpha bioactivity in plasma is, in fact, decreased in rats undergoing CCI.
Gene_expression (expression) of TNFalpha in plasma
13) Confidence 0.78 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12132059 Disease Relevance 0 Pain Relevance 0
In conclusion, mild hemorrhagic shock produced increases in superoxide and PGE2 production, and decreases in TNFalpha production by Kupffer cells, changes that may be appropriate to defend against the infectious challenges that often follows trauma and hemorrhage.
Gene_expression (production) of TNFalpha in PGE2 associated with injury, cva and hemorrhagic shock
14) Confidence 0.78 Published 2001 Journal Shock Section Abstract Doc Link 11336202 Disease Relevance 0.65 Pain Relevance 0.12
At this dosage, the expressions of c-Fos, TNF-alpha, and IL-1beta in the spinal cord were significantly inhibited.
Gene_expression (expressions) of TNF-alpha in spinal cord associated with spinal cord
15) Confidence 0.78 Published 2008 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18955812 Disease Relevance 0.83 Pain Relevance 0.74
Amygdalin (0.005, 0.05, and 0.1 mg/kg) was intramuscularly injected immediately after the induction of carrageenan-induced arthritic pain in rats, and the anti-arthritic effect of amygdalin was assessed by measuring the weight distribution ratio of the bearing forces of both feet and the ankle circumference, and by analyzing the expression levels of three molecular markers of pain and inflammation (c-Fos, TNF-alpha, and IL-1beta) in the spinal cord.
Spec (analyzing) Gene_expression (expression) of TNF-alpha in spinal cord associated with pain, inflammation, arthritis and spinal cord
16) Confidence 0.78 Published 2008 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18955812 Disease Relevance 0.91 Pain Relevance 0.73
Impairment of TNF-alpha expression and secretion in primary rat liver cell cultures by acetaminophen treatment.
Gene_expression (expression) of TNF-alpha in liver associated with paracetamol
17) Confidence 0.78 Published 1999 Journal Toxicology Section Title Doc Link 10378475 Disease Relevance 0.29 Pain Relevance 0.43
The results suggest that inhibition of TNF-alpha expression and release in the liver is a consequence of acetaminophen exposure.
Gene_expression (expression) of TNF-alpha in liver associated with paracetamol
18) Confidence 0.78 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.19 Pain Relevance 0.52
We used primary rat hepatocyte and Kupffer cell cultures to test the direct action of subtoxic and toxic concentrations of acetaminophen on TNF-alpha expression and release.
Gene_expression (expression) of TNF-alpha in Kupffer cell associated with paracetamol
19) Confidence 0.78 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.24 Pain Relevance 0.46
RESULTS: The 17-kDa form of tumor necrosis factor-alpha is expressed by herniated nucleus pulposus at a concentration of approximately 0.48 ng per herniated rat lumbar disc.
Gene_expression (expressed) of tumor necrosis factor-alpha in nucleus pulposus
20) Confidence 0.78 Published 2000 Journal Spine Section Body Doc Link 11145807 Disease Relevance 0.06 Pain Relevance 0

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