INT9159

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2003
Negated 3
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.05
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
hypothalamus 2
neurons 2
striatum 2
external 2
astrocytes 2
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 29 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Deafferentation 1 100.00 Very High Very High Very High
substance P 7 99.52 Very High Very High Very High
cytokine 5 82.88 Quite High
Opioid 4 75.00 Quite High
opiate 1 75.00 Quite High
medulla 1 75.00 Quite High
nMDA receptor 3 69.76 Quite High
Endogenous opioid 1 67.36 Quite High
Disease Link Frequency Relevance Heat
Necrosis 6 99.24 Very High Very High Very High
Cancer 6 99.06 Very High Very High Very High
Disease 18 98.60 Very High Very High Very High
Death 2 95.28 Very High Very High Very High
Body Weight 3 87.96 High High
Aids-related Complex 7 81.28 Quite High
Eating Disorder 4 79.44 Quite High
Injury 1 5.00 Very Low Very Low Very Low
Central Nervous System Disease 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic dizocilpine maleate (MK-801) treatment suppresses the effects of nigrostriatal dopamine deafferentation on enkephalin but not on substance P expression in the rat striatum.
Negative_regulation (suppresses) of Neg (not) Regulation (effects) of enkephalin in striatum associated with dopamine, enkephalin, substance p and deafferentation
1) Confidence 0.43 Published 1996 Journal Eur. J. Neurosci. Section Title Doc Link 8743739 Disease Relevance 0 Pain Relevance 0.99
In experiment 2, 48 h deprivation significantly decreased mRNA levels of proDyn and POMC by 23.7% (P < 0.05) and 45.6% (P < 0.01), respectively, whereas 24 h food deprivation decreased POMC mRNA by 43.% (P < 0.01). proEnk mRNA was not affected by 24- or 48-h food deprivation.
Negative_regulation (deprivation) of Neg (not) Regulation (affected) of proEnk
2) Confidence 0.40 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8928900 Disease Relevance 0.62 Pain Relevance 0.28
Inhibition of Ca2+ influx prevented the effects of KCl-induced depolarization on the rise in Leu-Enk and on prepro-EK.
Negative_regulation (prevented) of Regulation (effects) of Leu-Enk
3) Confidence 0.36 Published 1988 Journal Brain Res. Section Abstract Doc Link 3129130 Disease Relevance 0 Pain Relevance 0.23
Tumor necrosis factor-alpha treatment was unable to reverse the inhibitory effect of gamma-interferon pretreatment on proenkephalin messenger RNA levels in the astrocytes.
Neg (unable) Negative_regulation (reverse) of Regulation (effect) of proenkephalin in astrocytes associated with necrosis and cancer
4) Confidence 0.31 Published 1992 Journal Endocrinology Section Abstract Doc Link 1396335 Disease Relevance 0.95 Pain Relevance 0.30
The aim of this study was to examine prolactin (PRL) regulation of preproenkephalin and proopiomelanocortin (POMC) gene expression in the hypothalamus during lactation.
Spec (examine) Negative_regulation (examine) of Spec (examine) Regulation (regulation) of preproenkephalin in hypothalamus
5) Confidence 0.22 Published 2003 Journal Endocrine Section Abstract Doc Link 12668876 Disease Relevance 0.15 Pain Relevance 0
They also suggest that the early loss of enkephalin immunoreactivity observed in the external globus pallidus of presymptomatic carriers of the HD allele is not related to a generalized death of striatal enkephalinergic neurons early in the course of the disease.
Negative_regulation (loss) of Regulation (immunoreactivity) of enkephalin in neurons associated with enkephalin, disease and death
6) Confidence 0.13 Published 1991 Journal Ann. Neurol. Section Abstract Doc Link 1838677 Disease Relevance 0.78 Pain Relevance 0.28
In the specimens from presymptomatic individuals, there was no reduction of areal density of preproenkephalin messenger RNA-containing neurons in the striatum, despite the fact that loss of enkephalin immunoreactivity in the external globus pallidus had been previously demonstrated in the same brains.
Negative_regulation (loss) of Regulation (immunoreactivity) of enkephalin in external associated with enkephalin
7) Confidence 0.13 Published 1991 Journal Ann. Neurol. Section Abstract Doc Link 1838677 Disease Relevance 0.54 Pain Relevance 0.33

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