INT91598

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
somatotrope 2
motoneurons 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 5 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Spinal cord 28 93.28 High High
Serotonin 11 91.76 High High
sSRI 3 91.20 High High
Clonidine 1 88.24 High High
depression 1 86.36 High High
antagonist 3 82.00 Quite High
5HT 2 62.32 Quite High
agonist 2 61.56 Quite High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 17 95.52 Very High Very High Very High
Depression 1 86.36 High High
Urological Neuroanatomy 4 79.56 Quite High
Spinal Cord Compression 8 62.12 Quite High
Injury 14 16.88 Low Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Paraplegia 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect may be mediated at the hypothalamic level via reduced 5-HT1A receptor function or at the pituitary level, either by a direct effect on somatotrope cells or via enhanced insulin-like growth factor-1 (IGF-1) or somatostatin (SS) release.
Positive_regulation (enhanced) of Localization (release) of 5-HT1A in somatotrope associated with somatostatin
1) Confidence 0.49 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11041314 Disease Relevance 0.09 Pain Relevance 0.23
Chronic fluoxetine-induced desensitization of 5-HT1A and 5-HT1B autoreceptors: regional differences and effects of WAY-100635.
Positive_regulation (fluoxetine-induced) of Localization (desensitization) of 5-HT1A associated with fluoxetine
2) Confidence 0.49 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 14751404 Disease Relevance 0.07 Pain Relevance 0.56
Four weeks after non-integrating-Ngn2-hENPs transplantation, sub-cellular localization of 5HT1A expression was entirely restored to intact pattern since 92.3% of alpha-motoneurons displayed 5HT1A expression at the membrane (Figure 3I, K and L).
Positive_regulation (restored) of Localization (localization) of 5HT1A in motoneurons
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.36 Pain Relevance 0.25

General Comments

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