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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.23

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plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
somatotrope 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 1 100.00 Very High Very High Very High
Serotonin 1 92.08 High High
Clonidine 1 88.56 High High
depression 1 86.68 High High
Disease Link Frequency Relevance Heat
Depression 1 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect may be mediated at the hypothalamic level via reduced 5-HT1A receptor function or at the pituitary level, either by a direct effect on somatotrope cells or via enhanced insulin-like growth factor-1 (IGF-1) or somatostatin (SS) release.
Negative_regulation (reduced) of Localization (release) of 5-HT1A in somatotrope associated with somatostatin
1) Confidence 0.41 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11041314 Disease Relevance 0.09 Pain Relevance 0.23

General Comments

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