INT9160

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 16.37
Pain Relevance 11.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
lymph node 4
spleen 2
lymphocytes 2
T cells 2
plasma 1
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 46 99.98 Very High Very High Very High
Inflammation 58 99.80 Very High Very High Very High
antidepressant 10 99.70 Very High Very High Very High
Neuritis 75 99.38 Very High Very High Very High
chemokine 11 99.28 Very High Very High Very High
Serotonin 5 98.94 Very High Very High Very High
antagonist 24 98.74 Very High Very High Very High
opioid receptor 1 98.50 Very High Very High Very High
Enkephalin 3 98.32 Very High Very High Very High
Pain 22 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 4 100.00 Very High Very High Very High
Cancer 9 99.92 Very High Very High Very High
INFLAMMATION 64 99.80 Very High Very High Very High
Immunization 9 99.70 Very High Very High Very High
Necrosis 9 99.68 Very High Very High Very High
Experimental Autoimmune Neuritis 75 99.52 Very High Very High Very High
Primary Sclerosing Cholangitis 8 99.38 Very High Very High Very High
Leukemia 3 97.88 Very High Very High Very High
Disease Progression 2 97.04 Very High Very High Very High
Pressure Volume 2 Under Development 5 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen and mu-opioid receptor antagonists counteract the 17 beta-estradiol-induced licking increase and interferon-gamma reduction occurring during the formalin test in male rats.
Negative_regulation (reduction) of interferon-gamma associated with pain, antagonist and opioid receptor
1) Confidence 0.58 Published 2004 Journal Pain Section Title Doc Link 15327822 Disease Relevance 0.57 Pain Relevance 0.84
This was accompanied by a significant reduction in mRNA levels for IFN-gamma and inducible nitric oxide synthase.
Negative_regulation (reduction) of IFN-gamma
2) Confidence 0.57 Published 2002 Journal Acta Neuropathol. Section Abstract Doc Link 11810178 Disease Relevance 0.64 Pain Relevance 0.20
Similar studies were performed with inhibitors of IFN-gamma; hydrocortisone, cyclosporin A, dibutyryl cyclic AMP, methyl-xanthine and prostaglandin E2.
Negative_regulation (inhibitors) of IFN-gamma
3) Confidence 0.48 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1899426 Disease Relevance 0.41 Pain Relevance 0.37
Interferon-gamma inhibition suppresses experimental allergic neuritis: modulation of major histocompatibility complex expression of Schwann cells in vitro.
Negative_regulation (inhibition) of Interferon-gamma in Schwann cells associated with experimental autoimmune neuritis and neuritis
4) Confidence 0.48 Published 1991 Journal J. Neuroimmunol. Section Title Doc Link 1899426 Disease Relevance 0.42 Pain Relevance 0.38
Formalin decreased IFN-gamma in both Intact and GDX groups.
Negative_regulation (decreased) of IFN-gamma
5) Confidence 0.43 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.14 Pain Relevance 0.22
Addition of recombinant rat interferon-gamma (IFN-gamma) to beating rat atria decreased the contractile strength in a dose-dependent manner.
Negative_regulation (decreased) of IFN-gamma
6) Confidence 0.43 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1900518 Disease Relevance 0 Pain Relevance 0.13
The initial and prolonged reflex facilitations by IFN-gamma were partially and totally blocked, respectively, by i.t. pretreatment with nitro-L-arginine-ester, an inhibitor of nitric oxide synthase, at doses which did not influence spinal cord blood flow.
Negative_regulation (blocked) of IFN-gamma in blood associated with spinal cord
7) Confidence 0.43 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7715823 Disease Relevance 0.36 Pain Relevance 0.35
Amelioration of experimental allergic neuritis by sodium fusidate (fusidin): suppression of IFN-gamma and TNF-alpha and enhancement of IL-10.
Negative_regulation (suppression) of IFN-gamma associated with experimental autoimmune neuritis and neuritis
8) Confidence 0.39 Published 1999 Journal J. Autoimmun. Section Title Doc Link 10479387 Disease Relevance 0.69 Pain Relevance 0.40
RESULTS: Rats treated with DHEA at different doses displayed significant decreases in numbers of IFN-gamma, TNF-alpha expressing cells in the PNS (P<0.05), BPM-stimulated T cell proliferation (P<0.05), IFN-gamma, TNF-alpha secretion in draining lymph node and spleen (P<0.05) compared to control group.
Negative_regulation (decreases) of IFN-gamma in spleen
9) Confidence 0.36 Published 2008 Journal Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Section Body Doc Link 20104686 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Rats treated with DHEA at different doses displayed significant decreases in numbers of IFN-gamma, TNF-alpha expressing cells in the PNS (P<0.05), BPM-stimulated T cell proliferation (P<0.05), IFN-gamma, TNF-alpha secretion in draining lymph node and spleen (P<0.05) compared to control group.
Negative_regulation (numbers) of IFN-gamma in spleen
10) Confidence 0.36 Published 2008 Journal Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Section Body Doc Link 20104686 Disease Relevance 0.07 Pain Relevance 0
The decrease in cellular responsiveness extended to a decrease in at least one T cell lymphokine, IFN-gamma.
Negative_regulation (decrease) of IFN-gamma in T cell
11) Confidence 0.32 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7515330 Disease Relevance 1.02 Pain Relevance 0.50
Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system.
Negative_regulation (down-regulation) of IFN-gamma in peripheral nervous system associated with chemokine, peripheral nervous system, inflammation, experimental autoimmune neuritis and neuritis
12) Confidence 0.26 Published 2000 Journal Autoimmunity Section Title Doc Link 11078155 Disease Relevance 1.25 Pain Relevance 0.87
The number of IFN-gamma sc was suppressed by the K+ channel openers in the same concentration range.
Negative_regulation (suppressed) of IFN-gamma
13) Confidence 0.24 Published 1994 Journal Autoimmunity Section Abstract Doc Link 7858108 Disease Relevance 0.39 Pain Relevance 0.44
The plasma levels of cytokines (IL-1beta, IL-6, TNF-alpha, and IFN-gamma) and hypoglycemia induced by LPS were also reduced by urgosedin.
Negative_regulation (reduced) of IFN-gamma in plasma associated with hypoglycemia and cytokine
14) Confidence 0.21 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15475835 Disease Relevance 0.74 Pain Relevance 0.23
The levels of immunoreactive Met-enkephalin-Arg6-Phe7 were increased by approximately 50% with tumor necrosis factor-alpha and decreased by approximately 40% with gamma-interferon relative to untreated controls.
Negative_regulation (decreased) of gamma-interferon associated with necrosis, cancer and enkephalin
15) Confidence 0.19 Published 1992 Journal Endocrinology Section Abstract Doc Link 1396335 Disease Relevance 0.88 Pain Relevance 0.30
The region from -74 to -125 of the CTGF promoter was revealed to be critical for its activity in PSC as well as for the inhibitory effect of interferon-gamma.
Negative_regulation (effect) of interferon-gamma in PSC associated with primary sclerosing cholangitis
16) Confidence 0.18 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18639630 Disease Relevance 0.99 Pain Relevance 0.11
Linomide strongly suppressed IFN-gamma and lipopolysaccharide (LPS)-induced IL-1 beta, TNF-alpha and IL-6 mRNA expression in macrophages in vitro as demonstrated by in situ hybridisation.
Negative_regulation (suppressed) of IFN-gamma in macrophages
17) Confidence 0.17 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9184648 Disease Relevance 0.89 Pain Relevance 0.69
These data suggest that TAK-603 acts on the immune system, especially on cellular immunity. (2) In vitro: TAK-603 suppressed the mitogen-induced proliferation of mouse lymphocytes and the ConA-induced IFN-gamma and IL-2 production by rat lymphocytes at 10(-7) to 10(-5) M.
Negative_regulation (suppressed) of IFN-gamma in lymphocytes
18) Confidence 0.16 Published 1996 Journal Immunopharmacology Section Abstract Doc Link 8880222 Disease Relevance 0.74 Pain Relevance 0.18
The levels of pro-inflammatory cytokines interferon-gamma and interleukin-17 were strongly diminished.
Negative_regulation (diminished) of interferon-gamma associated with inflammation and cytokine
19) Confidence 0.14 Published 2010 Journal Brain Section Abstract Doc Link PMC2892943 Disease Relevance 0.42 Pain Relevance 0.29
VPA (300 mg/kg, intraperitoneally) administration to EAN rats once daily immediately following immunization significantly suppressed mRNA levels of interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-6 and IL-17 in the lymph nodes of EAN rats.
Negative_regulation (suppressed) of interferon-gamma in lymph nodes associated with necrosis, cancer, immunization and neuritis
20) Confidence 0.14 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18953683 Disease Relevance 1.35 Pain Relevance 0.98

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