INT91608

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Context Info
Confidence 0.40
First Reported 2000
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 2.04

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pigmentation (ASIP) signal transduction (ASIP) generation of precursor metabolites and energy (ASIP)
extracellular space (ASIP) extracellular region (ASIP) cell-cell signaling (ASIP)
ASIP (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 32 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Skin Cancer 5 99.32 Very High Very High Very High
Microphthalmia 1 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, ASIP down-regulation of tyrp1 was observed at the translational level.
Negative_regulation (down-regulation) of ASIP
1) Confidence 0.40 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12519127 Disease Relevance 0.51 Pain Relevance 0.29
The MC1R is also the principal mediator of the inhibitory effects of agouti signaling protein (ASP) on melanogenesis.
Negative_regulation (effects) of agouti signaling protein associated with melanocortin 1 receptor
2) Confidence 0.29 Published 2000 Journal Pigment Cell Res. Section Abstract Doc Link 11041375 Disease Relevance 0 Pain Relevance 0.87
The MC1R is also the principal mediator of the inhibitory effects of agouti signaling protein (ASP) on melanogenesis.
Negative_regulation (effects) of ASP associated with melanocortin 1 receptor
3) Confidence 0.29 Published 2000 Journal Pigment Cell Res. Section Abstract Doc Link 11041375 Disease Relevance 0 Pain Relevance 0.88

General Comments

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