INT91609

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 11
Total Number 16
Disease Relevance 2.75
Pain Relevance 7.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
NHM 12
skin 7
keratinocytes 4
kidney 2
hair 1
MC1R (Homo sapiens)
MC1R - V92M (1)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 107 100.00 Very High Very High Very High
ischemia 2 99.40 Very High Very High Very High
Inflammation 5 96.00 Very High Very High Very High
Neuropeptide 3 87.16 High High
cytokine 2 85.76 High High
Kinase C 4 69.80 Quite High
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acne 10 99.60 Very High Very High Very High
Cv Unclassified Under Development 2 99.40 Very High Very High Very High
Reperfusion Injury 1 99.04 Very High Very High Very High
Skin Cancer 6 97.80 Very High Very High Very High
Apoptosis 1 96.44 Very High Very High Very High
INFLAMMATION 5 96.00 Very High Very High Very High
Injury 2 94.36 High High
Erythema 1 92.24 High High
Microphthalmia 2 89.64 High High
Stress 4 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in the responses of NHM to some of these factors suggest differential regulation of MC1R gene expression, which may contribute to the variation in constitutive and UV-induced cutaneous pigmentation in humans.
Regulation (regulation) of Gene_expression (expression) of MC1R in NHM associated with melanocortin 1 receptor
1) Confidence 0.62 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.79
The aim of this study is to investigate the regulation of the human melanocortin 1 receptor (MC1R) expression in cultured normal human melanocytes (NHM) by specific paracrine and endocrine factors, and by ultraviolet radiation (UVR).
Spec (investigate) Regulation (regulation) of Gene_expression (expression) of MC1R in NHM associated with melanocortin 1 receptor
2) Confidence 0.62 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.51
Cell surface expression of melanocortin-1 receptor on HaCaT keratinocytes and alpha-melanocortin stimulation do not affect the formation and repair of UVB-induced DNA photoproducts.
Neg (not) Regulation (affect) of Gene_expression (expression) of melanocortin-1 receptor in keratinocytes associated with melanocortin 1 receptor
3) Confidence 0.61 Published 2007 Journal Photochem. Photobiol. Sci. Section Title Doc Link 17487313 Disease Relevance 0 Pain Relevance 0.52
Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation.
Regulation (Regulation) of Gene_expression (expression) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
4) Confidence 0.54 Published 2002 Journal Pigment Cell Res. Section Title Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.78
Recent studies that we conducted on the expression of MC1R variants by human melanocytes and the implications of these variants on the function of the MC1R revealed the following.
Regulation (conducted) of Gene_expression (expression) of MC1R in melanocytes associated with melanocortin 1 receptor
5) Confidence 0.45 Published 2000 Journal Pigment Cell Res. Section Abstract Doc Link 11041375 Disease Relevance 0 Pain Relevance 0.96
The aim of this study is to investigate the regulation of the human melanocortin 1 receptor (MC1R) expression in cultured normal human melanocytes (NHM) by specific paracrine and endocrine factors, and by ultraviolet radiation (UVR).
Spec (investigate) Regulation (regulation) of Gene_expression (expression) of melanocortin 1 receptor in NHM associated with melanocortin 1 receptor
6) Confidence 0.39 Published 2002 Journal Pigment Cell Res. Section Abstract Doc Link 12453185 Disease Relevance 0 Pain Relevance 0.51
Another culture, which was homozygous for Val92Met mutation in the MC1R, demonstrated a normal response to alpha-MSH.
Regulation (homozygous) of Gene_expression (mutation) of MC1R (V92M) associated with melanocortin 1 receptor
7) Confidence 0.39 Published 2000 Journal Pigment Cell Res. Section Abstract Doc Link 11041375 Disease Relevance 0 Pain Relevance 0.97
The effect of thioredoxin on the expression of proopiomelanocortin-derived peptides, the melanocortin 1 receptor and cell survival of normal human keratinocytes.
Regulation (effect) of Gene_expression (expression) of melanocortin 1 receptor in keratinocytes associated with melanocortin 1 receptor
8) Confidence 0.38 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Title Doc Link 11764282 Disease Relevance 0.05 Pain Relevance 0.21
The aim of this study was to determine, whether ultraviolet irradiation affects the expression of both alpha-melanocyte-stimulating hormone and the melanocortin-1 receptor in human epidermis in vivo.
Spec (whether) Regulation (affects) of Gene_expression (expression) of melanocortin-1 receptor in epidermis associated with melanocortin 1 receptor
9) Confidence 0.33 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15009732 Disease Relevance 0.48 Pain Relevance 0.31
The purpose of the study was to investigate by immunohistochemistry if changes of melanocortin-1 receptor expression exist in acne lesions versus normal skin.
Spec (investigate) Regulation (changes) of Gene_expression (expression) of melanocortin-1 receptor in skin associated with melanocortin 1 receptor and acne
10) Confidence 0.27 Published 2007 Journal Exp. Dermatol. Section Abstract Doc Link 17576233 Disease Relevance 1.11 Pain Relevance 0.40
We investigated whether MITF regulates human MC1R gene expression through the same transcriptional mechanism as tyrosinase and TRP-1 genes in melanocytes.
Spec (whether) Regulation (through) of Gene_expression (expression) of MC1R gene in melanocytes associated with melanocortin 1 receptor
11) Confidence 0.27 Published 2002 Journal Life Sci. Section Abstract Doc Link 12204775 Disease Relevance 0.16 Pain Relevance 0.72
Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk.
Regulation (Altered) of Gene_expression (expression) of MC1R in skin associated with skin cancer
12) Confidence 0.26 Published 2005 Journal Hum. Mol. Genet. Section Title Doc Link 15972726 Disease Relevance 0.18 Pain Relevance 0.10
Soluble factors, such as proopiomelanocortin (POMC) derivatives, agouti signal protein (ASP) and others, regulate MC1R expression, leading to improved photoprotection via increased eumelanin synthesis or in contrast, inducing the switch to pheomelanin.
Regulation (regulate) of Gene_expression (expression) of MC1R
13) Confidence 0.23 Published 2005 Journal Peptides Section Abstract Doc Link 16005546 Disease Relevance 0.09 Pain Relevance 0.15
However, it is important to note that little is known about the regulatory mechanisms that govern the expression of MC1R at the intracellular level.
Regulation (govern) of Gene_expression (expression) of MC1R
14) Confidence 0.22 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0 Pain Relevance 0.09
Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk.
Regulation (Altered) of in hair Gene_expression (expression) of MC1R in skin associated with skin cancer
15) Confidence 0.09 Published 2005 Journal Hum. Mol. Genet. Section Title Doc Link 15972726 Disease Relevance 0.18 Pain Relevance 0.10
Change of melanocortin receptor expression in rat kidney ischemia-reperfusion injury.
Regulation (Change) of Gene_expression (expression) of melanocortin receptor in kidney associated with reperfusion injury and ischemia
16) Confidence 0.01 Published 2008 Journal Transplant. Proc. Section Title Doc Link 18790174 Disease Relevance 0.48 Pain Relevance 0.23

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