INT91618

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 7.99
Pain Relevance 7.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
fibroblast 6
ESCs 4
SH-SY5Y 2
MDMs 2
neurite 2
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 23 99.98 Very High Very High Very High
Cannabinoid 31 99.82 Very High Very High Very High
Glutamate 1 99.18 Very High Very High Very High
Opioid 10 99.12 Very High Very High Very High
aspirin 14 98.72 Very High Very High Very High
opioid receptor 8 98.58 Very High Very High Very High
antagonist 34 98.08 Very High Very High Very High
Osteoarthritis 267 98.04 Very High Very High Very High
Immobilon 3 98.00 Very High Very High Very High
tolerance 6 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 94 99.48 Very High Very High Very High
Nerve Sheath Neoplasms 66 98.64 Very High Very High Very High
Frailty 270 98.04 Very High Very High Very High
Rheumatoid Arthritis 297 97.76 Very High Very High Very High
Cancer 133 96.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 96.68 Very High Very High Very High
Neuroblastoma 5 95.52 Very High Very High Very High
Apoptosis 132 94.16 High High
Infection 18 92.08 High High
Increased Venous Pressure Under Development 5 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The importance of activated MAP kinases for DOR internalization is further demonstrated by glutamate and paclitaxel because these substances induce phosphorylation of ERK1/2 and concomitantly prevent DOR sequestration by etorphine.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of ERK1 associated with glutamate and immobilon
1) Confidence 0.67 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 1.02
Cell cycle analysis was carried out by flow cytometry, the phosphorylation of mitogen-activated protein kinases ERK1 and ERK2 was detected by Western blotting assay, and changes of calcium concentration were monitored by scanning intracellular fluorescence intensity.
Positive_regulation (detected) of Phosphorylation (phosphorylation) of ERK1
2) Confidence 0.67 Published 2004 Journal Toxicol In Vitro Section Abstract Doc Link 15130602 Disease Relevance 0.79 Pain Relevance 0.57
This allowed the cannabinoid CB1 agonist WIN55212-2 to stimulate ERK1/2 phosphorylation but resulted in a large reduction in the capacity of DAMGO to activate these kinases.
Positive_regulation (stimulate) of Phosphorylation (phosphorylation) of ERK1 associated with cannabinoid and agonist
3) Confidence 0.67 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.73
Functional coupling of G alpha(i2)/z to the opioid receptors was demonstrated by opioid-induced inhibition of adenylyl cyclase and stimulation of ERK1/2 phosphorylation in PTX-treated cells.
Positive_regulation (stimulation) of Phosphorylation (phosphorylation) of ERK1 associated with opioid receptor and opioid
4) Confidence 0.49 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043551 Disease Relevance 0.09 Pain Relevance 0.57
Intriguingly, we revealed remarkable defects in NT3-induced ERK1/2 phosphorylation and neurite outgrowth.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1 in neurite
5) Confidence 0.49 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20188729 Disease Relevance 0.55 Pain Relevance 0.28
Thrombin induced phosphorylation of ERK1/2 and p38 in MDMs.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1 in MDMs
6) Confidence 0.49 Published 2009 Journal Blood Section Abstract Doc Link 19652200 Disease Relevance 0.99 Pain Relevance 0.30
In this connection, PGE(2) and butaprost induced phosphorylation of extracellular signal-regulated kinases 1/2 (Erk1/2), whose down-regulation by RNA interference significantly attenuated PGE(2)-induced cell proliferation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Erk1
7) Confidence 0.49 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.53 Pain Relevance 0.10
These compounds induced phosphorylation of extracellular signal-regulated kinase1/2 (Erk1/2), whereas a dominant-negative inhibitor of mitogen-activate protein kinase kinase (MEK) 1 blocked the induction of ATF3.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Erk1
8) Confidence 0.49 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.17 Pain Relevance 0.05
In cultured endometrial stromal cells (ESCs), estrogen plus progesterone increased ERK1/2 phosphorylation within 15 min (P < 0.05).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK1 in ESCs
9) Confidence 0.45 Published 2008 Journal J. Clin. Endocrinol. Metab. Section Body Doc Link 18559923 Disease Relevance 0 Pain Relevance 0
Although estrogen alone did not induce ERK1/2 phosphorylation in normal ESCs, there was a significant response to estrogen in ESCs isolated from eutopic endometriotic endometrium (P < 0.05).
Neg (not) Positive_regulation (induce) of Phosphorylation (phosphorylation) of ERK1 in ESCs
10) Confidence 0.45 Published 2008 Journal J. Clin. Endocrinol. Metab. Section Body Doc Link 18559923 Disease Relevance 0 Pain Relevance 0
Preconditioning induced phosphorylation of ERK1/2 and CREB which, along with Ca(2+) spiking and OGD tolerance, was eliminated by tetrodotoxin.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1 associated with tetrodotoxin and tolerance
11) Confidence 0.45 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18845540 Disease Relevance 0.22 Pain Relevance 0.71
Occupancy by the agonist DAMGO (Tyr-d-Ala-Gly-N-methyl-Phe-Gly-ol) resulted in phosphorylation of the ERK1/2 MAP kinases, which was blocked by the opioid antagonist naloxone but not the cannabinoid CB1 receptor inverse agonist SR141716A.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of ERK1 associated with cannabinoid, antagonist, narcan, agonist and opioid
12) Confidence 0.45 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.65
Prolonged (12h) exposure of SH-SY5Y neuroblastoma cells to the mu-opioid receptor (MOPr) agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) causes homologous desensitization as well as heterologous desensitization of the extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation induced by insulin-like growth factor (IGF)-I.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK 1 in SH-SY5Y associated with neuroblastoma, agonist, enkephalin and opioid receptor
13) Confidence 0.45 Published 2010 Journal FEBS Lett. Section Abstract Doc Link 20643133 Disease Relevance 0.17 Pain Relevance 0.35
The functional relevance of the presence of these receptors has been confirmed by pharmacological studies demonstrating cannabinoid agonist-induced phosphorylation of the downstream signalling targets (ERK1 and ERK2) in fibroblast-like cells derived from OA and RA patients.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1 in fibroblast associated with cannabinoid, rheumatoid arthritis, agonist and osteoarthritis
14) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.15 Pain Relevance 0.95
M)-induced phosphorylation of ERK1 and ERK2 in fibroblast-like cells, significance was not reached (Figure 7).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1 in fibroblast
15) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.13 Pain Relevance 0.34
M)-induced phosphorylation of ERK1 and ERK2 in fibroblast-like cells (Figure 7).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1 in fibroblast
16) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.15 Pain Relevance 0.38
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Positive_regulation (activation) of Phosphorylation (dephosphorylation) of ERK-1 associated with aspirin
17) Confidence 0.18 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.64 Pain Relevance 0.65
Interestingly, exposure of the human MPNST-derived cells to EGF did not increase RAS-GTP levels, yet strongly induced phosphorylation of ERK1/2.
Neg (not) Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK1 associated with nerve sheath neoplasms
18) Confidence 0.13 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.87 Pain Relevance 0
Phosphorylation of ERK1/2 was upregulated by EGF stimulation at similar extents in treated and untreated cells (Fig. 5c).
Positive_regulation (upregulated) of Phosphorylation (Phosphorylation) of ERK1
19) Confidence 0.10 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.40 Pain Relevance 0
Separate blots were blocked overnight at 4°C in TBS with 5% BSA (Sigma) and 0.05% Tween-20 and incubated with Anti-phospho-Erk1/2 (1 ?
Positive_regulation (incubated) of Phosphorylation (phospho) of Erk1
20) Confidence 0.10 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0 Pain Relevance 0

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