INT9165

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.08
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MSLN) cell adhesion (MSLN) Golgi apparatus (MSLN)
plasma membrane (MSLN)
Anatomy Link Frequency
muscle 3
forearm 1
biceps brachii 1
MSLN (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 14 82.40 Quite High
Central nervous system 10 13.16 Low Low
Deep tissue 5 5.00 Very Low Very Low Very Low
nociceptor 5 5.00 Very Low Very Low Very Low
backache 5 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatigue 74 99.82 Very High Very High Very High
Cancer 28 95.68 Very High Very High Very High
Ovarian Cancer 92 91.40 High High
Pain 13 82.40 Quite High
Myalgia 12 75.00 Quite High
Disease 15 74.32 Quite High
Malignant Neoplastic Disease 3 57.28 Quite High
Carcinoma In Situ 1 54.72 Quite High
Cleidocranial Dysplasia 1 52.40 Quite High
Fallopian Tube Neoplasms 1 20.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On both sides a decrease of MPF and an increase of rms were found with increasing time and load, i.e. classical EMG signs of localized muscle fatigue.
Negative_regulation (decrease) of MPF in muscle associated with fatigue
1) Confidence 0.37 Published 1992 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 1396655 Disease Relevance 0.54 Pain Relevance 0.20
We therefore intend to proceed with evaluation of MUC16, WFDC2, MSLN and MMP7, all of which have sensitivity >30% at 98% specificity in detection of clinically apparent serous cancers, beginning with analysis of serum specimens collected months to years prior to diagnosis of serous ovarian cancers.
Negative_regulation (evaluation) of MSLN associated with cancer and ovarian cancer
2) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 1.02 Pain Relevance 0
Theoretically, this could result in increases in MMG amplitude and decreases in MMG MPF.
Negative_regulation (decreases) of MMG MPF
3) Confidence 0.25 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
It was suggested that the reductions in MMG amplitude and MPF may have been due to fatigue-induced decreases in motor unit firing rates (i.e. muscle wisdom) and/or reduced compliance in the biceps brachii muscle.
Negative_regulation (reductions) of MPF in biceps brachii associated with fatigue
4) Confidence 0.25 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0.10 Pain Relevance 0
It was suggested [71,72] that the decreases in MMG amplitude and MPF may have been due to fatigue-related reductions in motor unit firing rates (i.e. muscle wisdom) and/or de-recruitment of fast-twitch motor units.
Negative_regulation (decreases) of MPF in muscle associated with fatigue
5) Confidence 0.25 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0.17 Pain Relevance 0
Specifically, fatigue-induced decreases in MMG amplitude and MPF may reflect reductions in motor unit firing rates (muscle wisdom) and/or de-recruitment of fast-twitch motor units [71-74,82].
Negative_regulation (decreases) of MPF in muscle associated with fatigue
6) Confidence 0.19 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0.10 Pain Relevance 0
For example, Beck et al. [72] reported decreases in both MMG amplitude and MMG MPF for the biceps brachii during 50 consecutive maximal concentric isokinetic muscle actions of the forearm flexors at a velocity of 180°·s-1.
Negative_regulation (decreases) of MMG MPF in forearm
7) Confidence 0.18 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0.15 Pain Relevance 0

General Comments

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