INT91651

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
sympathetic 1


Pain Term Frequency Confidence Heat
bradykinin 5 98.74 Very High Very High Very High
qutenza 6 98.60 Very High Very High Very High
depression 1 92.68 High High
medulla 3 27.08 Quite Low
beta blocker 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Natriuresis 9 94.60 High High
Depression 1 92.68 High High
Hypertension 25 84.40 Quite High
Obesity 70 82.16 Quite High
Stress 3 75.00 Quite High
Diabetes Mellitus 6 75.00 Quite High
Hypotension 2 45.08 Quite Low
Cv Unclassified Under Development 1 8.28 Low Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests a certain level of peripheral leptin resistance, probably as a result of several factors including renal receptor down-regulation induced by long-standing hyperleptinemia (Coatmellec-Taglioni et al 2003) and/or the presence of chronic antinatriuretic mechanisms, typical of these states, such as an enhanced RSNA and renin┬ľangiotensin system (Villarreal et al 1998; Beltowski, Wojcicka, Gorny, et al 2002), which may have overcome leptin-mediated natriuresis.
Positive_regulation (enhanced) of RSNA associated with natriuresis
1) Confidence 0.49 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 0.47 Pain Relevance 0
In vagal-denervated rats, Caps and BK (1-10.0 microg) evoked a sympathetic afferent-mediated reflex elevation of RSNA and MABP, which also was significantly blunted in STZ-treated rats (P < 0.05).
Positive_regulation (elevation) of RSNA in sympathetic associated with qutenza and bradykinin
2) Confidence 0.45 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11045951 Disease Relevance 0.37 Pain Relevance 0.70

General Comments

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