INT91653

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CASP1, IL18) cytosol (CASP1, IL18) intracellular (CASP1)
cell-cell signaling (IL18) signal transduction (CASP1) peptidase activity (CASP1)
Anatomy Link Frequency
monocytes 2
CASP1 (Homo sapiens)
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 8 91.92 High High
cytokine 4 72.56 Quite High
cINOD 2 41.68 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data indicate that incubating human monocytes with NCX-4016 causes intracellular NO formation and suppresses IL-1beta and IL-18 processing by inhibiting caspase-1 activity.
Negative_regulation (inhibiting) of caspase-1 in monocytes Negative_regulation (suppresses) of IL-18
1) Confidence 0.39 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.20

General Comments

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