INT91655

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Context Info
Confidence 0.02
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.43
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SLC8A1) intracellular (CASP1) cytoplasm (CASP1)
transmembrane transport (SLC8A1) cytosol (CASP1) signal transduction (CASP1)
SLC8A1 (Homo sapiens)
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 99.60 Very High Very High Very High
aspirin 16 95.60 Very High Very High Very High
cINOD 4 68.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of caspase-1 by NCX-4016 was reversible by the addition of DTT, which is consistent with S-nitrosylation as the mechanism of caspase-1 inhibition.
NCX-4016 Negative_regulation (inhibition) of caspase-1
1) Confidence 0.02 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.21 Pain Relevance 0.37
NCX-4016, similar to the NO donor S-nitroso-N-acetyl-D-L-penicillamine, inhibited caspase-1 activity with an EC(50) of approximately 20 microM.
NCX-4016 Negative_regulation (inhibited) of caspase-1
2) Confidence 0.01 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.22 Pain Relevance 0.39

General Comments

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