INT91657

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 15.97
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
monocytes 2
plasma 1
sputum 1
blood 1
osteoblasts 1
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 20 99.92 Very High Very High Very High
methotrexate 23 99.70 Very High Very High Very High
cytokine 410 99.20 Very High Very High Very High
rheumatoid arthritis 487 99.00 Very High Very High Very High
Inflammation 500 98.12 Very High Very High Very High
Osteoarthritis 105 97.94 Very High Very High Very High
metalloproteinase 14 94.08 High High
aspirin 21 91.96 High High
chemokine 85 89.32 High High
cINOD 22 87.88 High High
Disease Link Frequency Relevance Heat
Asthma 640 99.92 Very High Very High Very High
Cv General 3 Under Development 16 99.92 Very High Very High Very High
Atherosclerosis 46 99.84 Very High Very High Very High
Acute Coronary Syndrome 66 99.72 Very High Very High Very High
Syndrome 225 99.04 Very High Very High Very High
Rheumatoid Arthritis 487 99.00 Very High Very High Very High
INFLAMMATION 551 98.12 Very High Very High Very High
Osteoarthritis 106 97.94 Very High Very High Very High
Myocardial Infarction 67 97.48 Very High Very High Very High
Disease 207 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Negative_regulation (inhibition) of IL-18 in monocytes
1) Confidence 0.48 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
A specific inhibitor of IL-18 bioactivity, IL-18-binding protein (IL-18BP), down-regulated IL-12-induced IFN-?
Negative_regulation (inhibitor) of IL-18
2) Confidence 0.48 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.17 Pain Relevance 0.58
A specific inhibitor of IL-18 bioactivity, IL-18-binding protein (IL-18BP), down-regulated IL-12-induced IFN-?
Negative_regulation (inhibitor) of IL-18
3) Confidence 0.48 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.18 Pain Relevance 0.58
As for TWEAK, only addition of ethanolate produced an important IL-18 mRNA decrease (p?
Negative_regulation (decrease) of IL-18
4) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.04
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Negative_regulation (inhibition) of IL-18 in monocytes
5) Confidence 0.35 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
IL-18BP has been identified as a specific inhibitor of IL-18 [22,23].
Negative_regulation (inhibitor) of IL-18
6) Confidence 0.35 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.74 Pain Relevance 0.55
Moreover, animal models support the proatherogenic role of IL-18 as well as the beneficial effect of inhibiting IL-18 on plaque progression and composition.
Negative_regulation (inhibiting) of IL-18 in plaque associated with atherosclerosis
7) Confidence 0.24 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.01 Pain Relevance 0.32
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of IL-18 associated with methotrexate
8) Confidence 0.22 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.53 Pain Relevance 0.22
Indeed, in OA osteoblasts treated with either an inhibitor of PGE2 synthesis or exogenous PGE2 we observed a slight decrease in IL-18 or a slight increase, respectively (not shown).
Negative_regulation (decrease) of IL-18 in osteoblasts associated with osteoarthritis
9) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.52 Pain Relevance 0.23
As plasma IL-18 levels decrease with improving clinical status, IL-18 can be used as a surrogate for guided therapy [27].
Negative_regulation (decrease) of IL-18 in plasma
10) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.06 Pain Relevance 0.08
Inhibition of interleukin-18 reduced lesion progression with a decrease of inflammatory cells.
Negative_regulation (Inhibition) of interleukin-18 associated with inflammation
11) Confidence 0.15 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.91 Pain Relevance 0.59
Decreased levels of IL-18 in sputum and BAL from asthmatic patients compared to normal controls have also been reported [248,249].
Negative_regulation (Decreased) of IL-18 in sputum associated with asthma
12) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.69 Pain Relevance 0.26
With decreasing MCP-1 and IL-18, it can ameliorate cytokine-associated cardiac damage.
Negative_regulation (decreasing) of IL-18 associated with cytokine
13) Confidence 0.11 Published 2010 Journal Heart Vessels Section Abstract Doc Link 20339966 Disease Relevance 0.86 Pain Relevance 0.14
After treating with ramipril, the levels of MCP-1 and IL-18 were decreased in elderly patients with ACS.
Negative_regulation (decreased) of IL-18 associated with acute coronary syndrome
14) Confidence 0.11 Published 2010 Journal Heart Vessels Section Abstract Doc Link 20339966 Disease Relevance 1.02 Pain Relevance 0.15
Vaccination with allergen-IL-18 fusion DNA protects against, and reverses established, airway hyperresponsiveness in an animal model of asthma [241].
Negative_regulation (Vaccination) of allergen-IL-18 associated with asthma
15) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.91 Pain Relevance 0.18
In addition, peripheral blood mononuclear cells of RA patients show low levels of the IL-18 binding protein (a natural inhibitor of IL-18) and reduced sensitivity to stimulation with IL-12/IL-18, indicating profound dysregulation of the IL-18 system [61].


Negative_regulation (inhibitor) of IL-18 in mononuclear cells associated with rheumatoid arthritis
16) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.17 Pain Relevance 0.40
The clinical relevance of synovial IL-18 is emphasised by its correlation with the systemic levels of C-reactive protein (CRP); also, IL-18 and CRP decrease in parallel in synovial tissue and serum following effective treatment with disease-modifying anti-rheumatic drugs [60].
Negative_regulation (decrease) of IL-18 associated with disease
17) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.14 Pain Relevance 0.43
However, repletion of IL-12 p70, IL-18, IL-15, and IL-23 in postoperative blood failed to restore presurgical levels of IFNgamma synthesis (P < 0.05).
Negative_regulation (repletion) of IL-18 in blood
18) Confidence 0.04 Published 2005 Journal Shock Section Abstract Doc Link 15988317 Disease Relevance 0 Pain Relevance 0.16
Decreased epidermal staining for interleukin-1 and interleukin-6 were noted in other immunohistochemical studies; the investigators postulated that these findings were due to the release of these cytokines into the dermis [131].
Negative_regulation (Decreased) of interleukin-1 in dermis associated with cytokine
19) Confidence 0.02 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1963326 Disease Relevance 0.93 Pain Relevance 0.25
Interleukin-1 inhibitors
Negative_regulation (inhibitors) of Interleukin-1
20) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.64 Pain Relevance 0.21

General Comments

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