INT91658

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.89
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
Anatomy Link Frequency
macrophage 1
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 99.50 Very High Very High Very High
aspirin 8 98.88 Very High Very High Very High
cytokine 17 92.96 High High
Inflammation 26 91.48 High High
cINOD 2 53.24 Quite High
Bile 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 3 96.56 Very High Very High Very High
INFLAMMATION 28 91.48 High High
Apoptosis 4 88.96 High High
Death 1 87.76 High High
Neurodegenerative Disease 1 85.44 High High
Neonatal Necrotizing Enterocolitis 1 55.16 Quite High
Bacterial Respiratory Disease 4 41.20 Quite Low
Infection 40 32.84 Quite Low
Toxicity 1 31.84 Quite Low
Fever 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCX-4016, but not aspirin, prevented ICE activation as measured by assessing the release of ICE p20 subunit.
Localization (release) of ICE associated with aspirin
1) Confidence 0.77 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.20 Pain Relevance 0.37
These data indicate that therapeutic concentrations of acetaminophen induce an inhibition of IL-1beta-dependent NF-kappaB nuclear translocation.
Localization (translocation) of IL-1beta-dependent associated with paracetamol
2) Confidence 0.31 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.48
This, in turn, leads to multimerization of ASC and subsequent recruitment and activation of Caspase-1.
Localization (recruitment) of Caspase-1
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.06 Pain Relevance 0.03
release from macrophage after caspase-1/inflammasome activation had already been instigated by P2X7R stimulation.
Localization (release) of caspase-1 in macrophage
4) Confidence 0.05 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.09 Pain Relevance 0.09
They mediate proinflammatory signals through activation of caspase-1 and NF-?
Localization (caspase-1) of caspase-1
5) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.53 Pain Relevance 0.08

General Comments

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