INT91661

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.35
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 8 99.96 Very High Very High Very High
cytokine 31 86.28 High High
addiction 6 79.92 Quite High
Potency 3 69.84 Quite High
cINOD 2 55.40 Quite High
Inflammation 30 51.40 Quite High
Inflammatory stimuli 6 24.76 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Neuropathic pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 3 97.94 Very High Very High Very High
INFLAMMATION 40 75.00 Quite High
Apoptosis 3 45.60 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCX-4016, but not aspirin, prevented ICE activation as measured by assessing the release of ICE p20 subunit.
Negative_regulation (prevented) of Positive_regulation (activation) of ICE associated with aspirin
1) Confidence 0.41 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.20 Pain Relevance 0.37
Although the mechanism of 10panx1-mimetic toxicity during prolonged application has not been investigated, it clearly differs from the rapid (non-toxic) inhibition of caspase-1 activation that occurs with brief (<30 min) applications of this inhibitor [40, 42, 56].
Negative_regulation (inhibition) of Positive_regulation (activation) of caspase-1 associated with toxicity
2) Confidence 0.03 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.15 Pain Relevance 0.13
Initially, panx1 was expected to be a conduit for the high K+ efflux subsequent to P2X7R activation, but inhibition of panx1 using 10panx1 inhibitory peptide abolished caspase-1 activation without altering P2X7R-mediated K+ efflux [40].
Negative_regulation (abolished) of Positive_regulation (activation) of caspase-1
3) Confidence 0.03 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Fig. 3Schematic depicting distinct models of the activation of caspase-1 and IL-1?
Negative_regulation (depicting) of Positive_regulation (activation) of caspase-1
4) Confidence 0.03 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0

General Comments

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