INT91663

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.91
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
macrophage 2
plasma 2
accessory cells 2
monocytes 2
lymphocytes 2
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 322 100.00 Very High Very High Very High
Inflammation 145 96.56 Very High Very High Very High
Neuropeptide 3 96.04 Very High Very High Very High
aspirin 8 92.80 High High
cINOD 2 88.72 High High
endometriosis 168 79.72 Quite High
fibrosis 21 74.96 Quite High
anesthesia 1 72.76 Quite High
chemokine 15 71.04 Quite High
bradykinin 1 69.04 Quite High
Disease Link Frequency Relevance Heat
Sepsis 56 98.58 Very High Very High Very High
INFLAMMATION 165 96.56 Very High Very High Very High
Toxicity 97 95.88 Very High Very High Very High
Stress 160 94.52 High High
Recurrence 24 91.04 High High
Cirrhosis 47 89.84 High High
Alcoholic Liver Diseases 19 86.48 High High
Endometriosis 224 79.72 Quite High
Nash(non-alcoholic Steatohepatitis) 12 78.44 Quite High
Disease 71 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
Positive_regulation (promote) of Localization (secretion) of IL-12
1) Confidence 0.27 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.47 Pain Relevance 0.24
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Positive_regulation (resulted) of Localization (release) of IL-12 in monocytes
2) Confidence 0.15 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
Insignificant decrease of plasma IL-12 and IL-10, negligible increase of Th1-cytokines, and persistence of IL-10, despite decrease in TGF-?
Positive_regulation (increase) of Localization (decrease) of IL-12 in plasma associated with cytokine
3) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.61 Pain Relevance 0.16
receptors.58 This activation of accessory cells leads to the secretion of cytokines such as IL-12, TNF-?
Positive_regulation (leads) of Localization (secretion) of IL-12 in accessory cells associated with cytokine
4) Confidence 0.10 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 0.82 Pain Relevance 0.10
However, they can also do the opposite in alcoholics exposed to high levels of LPS by releasing IL-12 and IL-18, which can recruit natural killer T cells as well as both CD8+ and CD4+ lymphocytes.
Positive_regulation (exposed) of Localization (releasing) of IL-12 in lymphocytes
5) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.34 Pain Relevance 0.19
, granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL12 prior to the first dose, 24 h after each dose, and at 6 and 12 h after the first and fifth dose.
Positive_regulation (macrophage) of Localization (granulocyte) of IL12 in macrophage
6) Confidence 0.04 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.54 Pain Relevance 0.06
In cultures of PBMCS, VAA-I increased the secretion of total IL-12 and its active p70 form (27).
Positive_regulation (increased) of Localization (secretion) of IL-12
7) Confidence 0.04 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.21 Pain Relevance 0.16
For example, GCs dampen the release of IL-12, IFN-?
Positive_regulation (dampen) of Localization (release) of IL-12
8) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.32 Pain Relevance 0.32
A recent study of cytokines expressed by 40 patients with septic shock, 20 of whom were treated with low doses of glucocorticoids, showed an increase in IL-12 secretion and did not show an increase in Th2 differentiation while under glucocorticoid treatment [12].
Positive_regulation (increase) of Localization (secretion) of IL-12 associated with sepsis and cytokine
9) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC420022 Disease Relevance 0.36 Pain Relevance 0.33

General Comments

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