INT91667

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Context Info
Confidence 0.74
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 25.51
Pain Relevance 7.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
macrophages 4
lymphocytes 4
T cells 4
DCs 2
monocytes 2
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1125 100.00 Very High Very High Very High
Inflammation 757 100.00 Very High Very High Very High
chemokine 121 100.00 Very High Very High Very High
Neuropeptide 4 95.60 Very High Very High Very High
psoriasis 21 94.40 High High
abdominal pain 4 92.56 High High
Inflammatory response 87 91.84 High High
aspirin 10 90.76 High High
Fibrositis 97 90.00 High High
tolerance 23 89.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 845 100.00 Very High Very High Very High
Cervical Cancer 82 99.84 Very High Very High Very High
Cancer 857 99.76 Very High Very High Very High
Fever 66 99.64 Very High Very High Very High
Chlamydia Infection 148 99.52 Very High Very High Very High
Necrosis 59 99.52 Very High Very High Very High
Carcinoma 135 99.36 Very High Very High Very High
Granuloma 24 99.08 Very High Very High Very High
Sepsis 124 98.34 Very High Very High Very High
Disease 506 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of phIL-12/PPC was generally safe and well-tolerated.
Localization (Administration) of phIL-12
1) Confidence 0.74 Published 2010 Journal Gene Ther. Section Abstract Doc Link 20033066 Disease Relevance 0.44 Pain Relevance 0.09
Nine patients were enrolled in this dose-escalation study, with secreted IL-12 doses ranging from 300 ng/24 hr for the first three patients to 1000, 3000, and 5000 ng/24 hr for two patients in each subsequent dosage level.
Localization (secreted) of IL-12
2) Confidence 0.70 Published 2001 Journal Hum. Gene Ther. Section Abstract Doc Link 11426466 Disease Relevance 0.50 Pain Relevance 0.06
Decreased macrophage function, including impaired chemotaxis, binding of microorganisms, phagocytosis, antigen processing, microbicidal activity and capacity to secrete interleukin-12 is recognized (30–34).
Localization (secrete) of interleukin-12 in macrophage
3) Confidence 0.68 Published 2006 Journal Parasite Immunology Section Body Doc Link PMC1636681 Disease Relevance 0.35 Pain Relevance 0.03
PRL alone was not able to induce any measurable secretion of TNF-alpha, IL-10, or IL-12 in non-stimulated, whole blood cultures.
Localization (secretion) of IL-12 in blood
4) Confidence 0.44 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.49 Pain Relevance 0.25
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
Localization (secretion) of IL-12
5) Confidence 0.44 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.46 Pain Relevance 0.24
and IL-12 release in cervical carcinoma are comparable
Localization (release) of IL-12 associated with cervical cancer
6) Confidence 0.32 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 1.36 Pain Relevance 0.38
IL-12 secretion in our study groups merits consideration.
Localization (secretion) of IL-12
7) Confidence 0.30 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.95 Pain Relevance 0.35
Our observation of high secretion of IL-12 in
Localization (secretion) of IL-12
8) Confidence 0.28 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.79 Pain Relevance 0.38
In spite of the expected relationship between IL-12 and IFN?
Localization (relationship) of IL-12
9) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.02 Pain Relevance 0.48
2 cells and treated with hrIL-12 developed tumors significantly smaller (P?
Localization (treated) of hrIL-12 associated with cancer
10) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.70 Pain Relevance 0
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Localization (release) of IL-12 in monocytes
11) Confidence 0.23 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.37
Indeed, IL-4 plays an important role in DC maturation [9] and promotes IL-12 secretion from DCs [10-12].
Localization (secretion) of IL-12
12) Confidence 0.21 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.95 Pain Relevance 0.18
, IL-12 and TNF and persistence of IL-10, despite decline in TGF-?
Localization (despite) of IL-12
13) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.24 Pain Relevance 0.04
When DCs or monocytes-macrophages encounter a pathogen and release cytokines such as IL-12, IL-15, IL-18, TNF-?
Localization (release) of IL-12 in monocytes associated with cytokine
14) Confidence 0.17 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.67 Pain Relevance 0.05
Insignificant decrease of plasma IL-12 and IL-10, negligible increase of Th1-cytokines, and persistence of IL-10, despite decrease in TGF-?
Localization (decrease) of IL-12 in plasma associated with cytokine
15) Confidence 0.17 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.60 Pain Relevance 0.16
receptors.58 This activation of accessory cells leads to the secretion of cytokines such as IL-12, TNF-?
Localization (secretion) of IL-12 in accessory cells associated with cytokine
16) Confidence 0.15 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 0.82 Pain Relevance 0.10
expression occurred after inhibition of p38 MAPK in the presence of IL-12, indicating that the p38 MAPK pathway is involved in mediating IL-12-induced IFN-?
Localization (presence) of IL-12
17) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.03
However, they can also do the opposite in alcoholics exposed to high levels of LPS by releasing IL-12 and IL-18, which can recruit natural killer T cells as well as both CD8+ and CD4+ lymphocytes.
Localization (releasing) of IL-12 in lymphocytes
18) Confidence 0.11 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.32 Pain Relevance 0.19
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Localization (secretion) of IL-12 in dendritic cells
19) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.63 Pain Relevance 0.24
DCs express TLRs, and as a result of TLR triggering, DCs upregulate co-stimulatory molecules, secrete immunomodulatory cytokines such as IL-12, and increase antigen processing and presentation to B and T lymphocytes.
Localization (secrete) of IL-12 in DCs associated with cytokine
20) Confidence 0.06 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.22 Pain Relevance 0.27

General Comments

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