INT91668

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
monocytes 2
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 94.64 High High
aspirin 8 92.80 High High
cINOD 2 88.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Positive_regulation (resulted) of Negative_regulation (inhibition) of IL-18 in monocytes
1) Confidence 0.38 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38

General Comments

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