INT91669

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.10
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
synovial fluid 3
blood 3
monocytes 2
T cells 2
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 32 100.00 Very High Very High Very High
cINOD 13 98.04 Very High Very High Very High
aspirin 9 94.72 High High
Inflammation 57 94.36 High High
fibrosis 10 94.32 High High
rheumatoid arthritis 8 89.64 High High
Inflammatory mediators 20 87.08 High High
depression 14 85.40 High High
methotrexate 4 82.32 Quite High
bradykinin 10 61.92 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Disease 2 95.32 Very High Very High Very High
Cystic Fibrosis 6 94.88 High High
INFLAMMATION 85 94.36 High High
Hypersensitivity 6 93.16 High High
Rheumatoid Arthritis 8 89.64 High High
Depression 14 85.40 High High
Necrosis 8 83.64 Quite High
Cancer 24 83.28 Quite High
Disease 37 80.32 Quite High
Suicidal Behaviour 2 80.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 immunoneutralization resulted in a 60-80% reduction of IL-1beta, IL-8, IFN-gamma, and TNF-alpha release from LPS-stimulated monocytes.
Negative_regulation (reduction) of Localization (release) of IFN-gamma in monocytes
1) Confidence 0.57 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.31
The selective inhibition of the early generation of IFN-gamma and TNF-alpha from NK and gammadelta T cells by NSAIDs may serve to drive the subsequent acquired immune responses towards a Th2 phenotype, leading to the aggravation of allergic symptoms.
Negative_regulation (inhibition) of Localization (generation) of IFN-gamma in T cells associated with hypersensitivity and cinod
2) Confidence 0.41 Published 2006 Journal Exp. Dermatol. Section Abstract Doc Link 17083365 Disease Relevance 0.68 Pain Relevance 0.96
Experiments revealed that blood mononuclear cells and lymphocytes with CFTR dysfunction exhibited a reduced potential for secretion of the cytokines IL-10 and IFN gamma [115,116].
Negative_regulation (reduced) of Localization (secretion) of IFN gamma in blood associated with cytokine
3) Confidence 0.25 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.43 Pain Relevance 0.37
Statins also led to significant suppression of collagen-specific Th 1 humoral and cellular immune responses, reduction of anti-CD3/anti-CD28 proliferation and IFN-gamma release from mononuclear cells derived from peripheral blood and synovial fluid [118].
Negative_regulation (reduction) of Localization (release) of IFN-gamma in synovial fluid
4) Confidence 0.11 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.41 Pain Relevance 0.47
Statins also led to significant suppression of collagen-specific Th 1 humoral and cellular immune responses, reduction of anti-CD3/anti-CD28 proliferation and IFN-gamma release from mononuclear cells derived from peripheral blood and synovial fluid [118].
Negative_regulation (reduction) of in blood Localization (release) of IFN-gamma in synovial fluid
5) Confidence 0.04 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.41 Pain Relevance 0.47

General Comments

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