INT9167

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.53
Pain Relevance 6.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Adora1) plasma membrane (Adora1) signal transducer activity (Adora1)
Anatomy Link Frequency
spinal nerve 1
cortex 1
Adora1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 64 100.00 Very High Very High Very High
Gabapentin 54 100.00 Very High Very High Very High
intrathecal 49 100.00 Very High Very High Very High
antiallodynic 19 99.98 Very High Very High Very High
agonist 23 99.96 Very High Very High Very High
Morphine 19 99.88 Very High Very High Very High
Eae 8 99.36 Very High Very High Very High
tolerance 6 98.00 Very High Very High Very High
Spinal cord 13 95.24 Very High Very High Very High
Antinociceptive 13 94.88 High High
Disease Link Frequency Relevance Heat
Nociception 10 87.96 High High
Neuropathic Pain 40 80.24 Quite High
Hypersensitivity 2 70.48 Quite High
Hyperalgesia 3 45.80 Quite Low
Cv Unclassified Under Development 1 44.40 Quite Low
Injury 11 44.00 Quite Low
Sleep Disorders 14 38.48 Quite Low
Nervous System Injury 5 15.08 Low Low
Ganglion Cysts 4 14.56 Low Low
Pain 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When A1 adenosine receptor binding was determined by using [3H]cyclohexyladenosine ([3H]CHA) a significant decrease in binding (P less than 0.05) in the spinal cord but not in the cortex was observed.
A1 adenosine receptor Binding (binding) of in cortex associated with adenocard and spinal cord
1) Confidence 0.40 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1396994 Disease Relevance 0 Pain Relevance 0.97
R-phenylisopropyl-adenosine, which has an affinity for the adenosine A1 receptor higher than that for the A2 receptor, and N-ethylcarboxamide-adenosine, which has near equal affinity for the A1 and A2 receptors, were injected intrathecally into rats to evaluate differences in antinociceptive effect and motor impairment.
adenosine A1 receptor Binding (affinity) of associated with adenocard and antinociceptive
2) Confidence 0.37 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2363530 Disease Relevance 0.07 Pain Relevance 0.54
There is no study on the antiallodynic interaction of intrathecal gabapentin and A1 adenosine receptor agonist in the spinal nerve ligation rat model.
A1 adenosine receptor Neg (no) Binding (interaction) of in spinal nerve associated with adenocard, eae, agonist, gabapentin, antiallodynic and intrathecal
3) Confidence 0.35 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526387 Disease Relevance 0.23 Pain Relevance 2.16
Animals were rendered tolerant to morphine, and A1 adenosine receptor binding activity was measured.
A1 adenosine receptor Binding (activity) of associated with adenocard and morphine
4) Confidence 0.34 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1396994 Disease Relevance 0 Pain Relevance 1.02
Animals were rendered tolerant to morphine, and A1 adenosine receptor binding activity was measured.
A1 adenosine receptor Binding (binding) of associated with adenocard and morphine
5) Confidence 0.34 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1396994 Disease Relevance 0 Pain Relevance 1.02
Therefore, our results may reflect both an adrenergic component of adenosine activity as well as other interactions between cholinesterase inhibitors and adenosine A1 receptor agonists.
adenosine A1 receptor Binding (interactions) of associated with adenocard and agonist
6) Confidence 0.20 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908226 Disease Relevance 0.22 Pain Relevance 1.19

General Comments

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