INT91673

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Context Info
Confidence 0.71
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.41
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a2) endoplasmic reticulum (Cyp3a2) enzyme binding (Cyp3a2)
cytoplasm (Cyp3a2)
Anatomy Link Frequency
livers 1
fat 1
Cyp3a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 1 92.20 High High
Oxycodone 4 50.00 Quite Low
IPN 1 50.00 Quite Low
Analgesic 1 48.56 Quite Low
Inflammation 5 10.00 Low Low
Pain 2 10.00 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 10 95.24 Very High Very High Very High
Hepatotoxicity 3 89.16 High High
Acute Liver Failure 3 82.00 Quite High
Toxicity 4 67.04 Quite High
Inflammatory Pain 1 50.00 Quite Low
Adenovirus Infection 7 41.92 Quite Low
Targeted Disruption 1 31.12 Quite Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Viral Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Repeated oxycodone administration is associated with a significant up-regulation of rGSTA5 and concomitant down-regulation of CYP3A2 mRNA, protein expression and functionality.
Transcription (expression) of CYP3A2
1) Confidence 0.71 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487198 Disease Relevance 0 Pain Relevance 0
Good correlations were observed between mRNA expression and enzyme activity of CYP2C11, CYP2E1, CYP3A2 and CYP1A2 in livers of rats given various doses of CCl(4).
Transcription (expression) of CYP3A2 in livers
2) Confidence 0.65 Published 2004 Journal Int J Pharm Section Abstract Doc Link 14706259 Disease Relevance 0.16 Pain Relevance 0.09
CYP3A1 mRNA levels were severely decreased by FCA administration, whereas CYP3A2 mRNA and protein levels remained unchanged.
Transcription (levels) of CYP3A2
3) Confidence 0.52 Published 2005 Journal Pharm. Res. Section Body Doc Link 15771231 Disease Relevance 0 Pain Relevance 0
These results indicate that 1) ethanol differentially affects the expression of CYP3A gene family and this regulation appears to be modulated by dietary CHO/fat ratio; 2) the decrease in testosterone 6 beta-hydroxylase activity and CYP3A apoprotein levels are most likely due to the ethanol-induced decrease in CYP3A2 mRNA levels; and 3) CYP3A9 is induced by ethanol and is a low-affinity, high-K(m) chlorzoxazone hydroxylase.
Transcription (levels) of CYP3A2 in fat
4) Confidence 0.49 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11046114 Disease Relevance 0 Pain Relevance 0
Transcription of CYP3A2 is thought to occur by heterodimerization of two orphan nuclear receptors, PXR and the retinoid × receptor alpha (RXR?)
Transcription (Transcription) of CYP3A2
5) Confidence 0.44 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.25 Pain Relevance 0

General Comments

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