INT917

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 51
Total Number 56
Disease Relevance 8.53
Pain Relevance 22.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
hypothalamus 4
gonadal 4
plasma 3
spinal cord 2
gonadotrophs 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 175 100.00 Very High Very High Very High
Opioid 45 100.00 Very High Very High Very High
Dopamine 19 100.00 Very High Very High Very High
antagonist 284 99.98 Very High Very High Very High
opiate 61 99.96 Very High Very High Very High
Locus ceruleus 1 99.64 Very High Very High Very High
Neurotransmitter 10 99.60 Very High Very High Very High
Delta opioid receptors 2 99.58 Very High Very High Very High
agonist 203 99.36 Very High Very High Very High
Endogenous opioid 40 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 24 99.98 Very High Very High Very High
Lifespan 9 99.60 Very High Very High Very High
Hypoglycemia 7 99.54 Very High Very High Very High
Reprotox - General 3 238 98.76 Very High Very High Very High
Androgen Insensitivity 2 97.64 Very High Very High Very High
Adrenal Cancer 416 97.36 Very High Very High Very High
Acth-secreting Pituitary Adenoma 3 97.20 Very High Very High Very High
Prostate Cancer 38 96.58 Very High Very High Very High
Hypertension 7 95.68 Very High Very High Very High
Precocious Puberty 17 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of sulpiride and naloxone on the changes in LH secretion induced by a metenkephalin analog (D-Ala2-MePhe4-Met-(o)-ol-Enkephalin, FK 33824, Sandoz, Basel, Switzerland) (DAMME) and dopamine infusion in four castrated men (21 to 25 years of age) were studied.
Positive_regulation (induced) of Localization (secretion) of LH associated with dopamine, narcan and enkephalin
1) Confidence 0.69 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.51
In addition, the administration of adrenergic inhibitors did not impede the capacity of naltrexone to significantly augment pulsatile LH secretion in these subjects.
Positive_regulation (augment) of Localization (secretion) of LH
2) Confidence 0.69 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.35
In addition, augmentation of pulsatile LH release in the rodent in response to opiate receptor antagonists is dependent upon intact central noradrenergic pathways.
Positive_regulation (augmentation) of Localization (release) of LH associated with antagonist and opiate
3) Confidence 0.69 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.22
Moreover, the effectiveness of naloxone in augmenting LH release decreases with advancing gestational age.
Positive_regulation (augmenting) of Localization (release) of LH associated with narcan
4) Confidence 0.69 Published 1985 Journal Endocrinology Section Abstract Doc Link 3987627 Disease Relevance 0 Pain Relevance 0.77
This study was designed to evaluate whether the tonic inhibitory effect on LH secretion induced by opiates involves the serotoninergic system.
Spec (whether) Positive_regulation (induced) of Localization (secretion) of LH associated with opiate
5) Confidence 0.69 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.67
Naloxone significantly stimulated LH secretion in all subjects, whereas serum FSH levels were similar during both saline and naloxone infusion.
Positive_regulation (stimulated) of Localization (secretion) of LH associated with narcan
6) Confidence 0.69 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6415088 Disease Relevance 0 Pain Relevance 0.42
Opiate antagonists can indirectly stimulate the secretion of luteinizing hormone (LH) and testosterone, as well as sexual functions in animals and humans.
Positive_regulation (stimulate) of Localization (secretion) of LH associated with antagonist and opiate
7) Confidence 0.68 Published 1993 Journal J. Androl. Section Abstract Doc Link 8294223 Disease Relevance 0.31 Pain Relevance 0.38
Naloxone increases bioactive LH in man: evidence for selective release of early LH pool.
Positive_regulation (increases) of Localization (release) of LH associated with narcan
8) Confidence 0.68 Published 1985 Journal J. Endocrinol. Invest. Section Title Doc Link 3914504 Disease Relevance 0 Pain Relevance 0.48
The study demonstrated that naloxone infusion significantly stimulated the LH secretion throughout the period of observation (P less than 0.01 versus saline).
Positive_regulation (stimulated) of Localization (secretion) of LH associated with narcan
9) Confidence 0.66 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 3979585 Disease Relevance 0 Pain Relevance 0.76
These results indicate that endogenous opioid peptides are involved in stress-induced PRL and LH release in humans.
Positive_regulation (induced) of Localization (release) of LH associated with stress and endogenous opioid
10) Confidence 0.64 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7085859 Disease Relevance 0.29 Pain Relevance 0.57
For the naloxone-induced increase in LH secretion to occur, relatively high levels of sex steroids are required.
Positive_regulation (increase) of Localization (secretion) of LH associated with narcan
11) Confidence 0.63 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.30
Effect of captopril, an inhibitor of the converting enzyme on naloxone induced secretion of ACTH and LH in man.
Positive_regulation (induced) of Localization (secretion) of LH associated with narcan
12) Confidence 0.58 Published 1993 Journal Horm. Metab. Res. Section Title Doc Link 8262463 Disease Relevance 0.08 Pain Relevance 0.81
In concordance with previous studies, naloxone infusion augmented the LRH-stimulated secretion of LH.
Positive_regulation (augmented) of Localization (secretion) of LH associated with narcan
13) Confidence 0.58 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3102338 Disease Relevance 0 Pain Relevance 0.30
These data indicate that activation of delta-opioid receptors can reduce naloxone-induced LH release, suggesting a possible role of delta receptors in opioidergic modulation of LH secretion in women.
Positive_regulation (induced) of Localization (release) of LH associated with narcan and delta opioid receptors
14) Confidence 0.56 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.51
Administration of opiate receptor antagonists augmented pulsatile LH release in six estrogen-treated, orchidectomized individuals with testicular feminization.
Positive_regulation (augmented) of Localization (release) of LH associated with antagonist, opiate and androgen insensitivity
15) Confidence 0.51 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 4031019 Disease Relevance 0.17 Pain Relevance 0.49
Five normal men underwent repetitive (every 20 min) venous sampling for 8 h to characterize episodic LH release quantitatively under basal conditions and after the administration of naltrexone, a potent opiate receptor antagonist which stimulates puslatile LH release.
Positive_regulation (characterize) of Localization (release) of LH associated with antagonist and opiate
16) Confidence 0.50 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.34
In addition, the administration of adrenergic inhibitors did not impede the capacity of naltrexone to significantly augment pulsatile LH secretion in these subjects.
Positive_regulation (augment) of Localization (secretion) of LH
17) Confidence 0.50 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.35
Fetuses of 94-115 days showed a significantly higher increment in LH secretion when given naloxone (112.3 +/- 30.7 ng/h ml-1) than did older fetuses of gestational age 126-143 days (64.8 +/- 20.8 ng/h ml-1) (P less than 0.02).
Positive_regulation (increment) of Localization (secretion) of LH associated with narcan
18) Confidence 0.50 Published 1985 Journal Endocrinology Section Abstract Doc Link 3987627 Disease Relevance 0 Pain Relevance 0.90
Gonadotropin secretion was assessed by repetitive venous sampling for 24 h to appraise the pulsatile features of LH release as well as by graded serum LH responses to GnRH.
Positive_regulation (responses) of Localization (release) of LH
19) Confidence 0.50 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3517031 Disease Relevance 0 Pain Relevance 0.41
Two experimental models were studied, and two sets of effects on LH secretion induced by intravenous naloxone infusion (20 mg over 2 hours) in 14 normal men 20 to 25 years of age were evaluated: the effect of oral sulpiride (150 mg), a potent dopaminergic antagonist, and the effect of oral fenfluramine (60 mg), a drug that stimulates the serotoninergic receptors by releasing serotonin and inhibiting its reuptake.
Positive_regulation (induced) of Localization (secretion) of LH associated with antagonist, narcan and serotonin
20) Confidence 0.48 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 3979585 Disease Relevance 0 Pain Relevance 0.61

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