INT91709

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.09
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (PGP)
Anatomy Link Frequency
neuronal 1
PGP (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 3 96.28 Very High Very High Very High
Paracetamol 1 95.68 Very High Very High Very High
abdominal pain 1 90.36 High High
Bioavailability 30 89.44 High High
antidepressant 2 88.36 High High
Endep 2 82.56 Quite High
Versed 14 78.96 Quite High
methadone 1 77.52 Quite High
aspirin 1 76.52 Quite High
Dextromethorphan 1 64.32 Quite High
Disease Link Frequency Relevance Heat
Metastasis 1 98.60 Very High Very High Very High
Cyst 2 94.08 High High
Toxicity 5 92.08 High High
Constipation 1 91.52 High High
Abdominal Pain 1 90.36 High High
Cancer 5 88.40 High High
Sarcoma 1 87.72 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 81.44 Quite High
Nerve Cancer 1 75.00 Quite High
Hypoglycemia 1 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both pharmacokinetic (e.g. induction of hepatic CYPs and intestinal PgP) and/or pharmacodynamic mechanisms (e.g. synergistic or antagonistic interaction on the same drug target) may be involved in drug-herb interactions, leading of altered drug clearance, response and toxicity.
Positive_regulation (induction) of PgP associated with toxicity
1) Confidence 0.69 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17168768 Disease Relevance 0.33 Pain Relevance 0.30
The available data indicate that St John's wort is a potent inducer of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs, depending on the dose, route and duration of administration.
Positive_regulation (inducer) of PgP
2) Confidence 0.67 Published 2004 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 15260917 Disease Relevance 0.05 Pain Relevance 0.27
Immunohistochemical staining was positive for vimentin, neuronal-specific enolase and PGP9.5.
Positive_regulation (positive) of PGP9 in neuronal
3) Confidence 0.13 Published 2000 Journal Dig Surg Section Abstract Doc Link 11053953 Disease Relevance 0.70 Pain Relevance 0.09
Earlier results have shown grapefruit juice to cause activation of Pgp in vitro [24].
Positive_regulation (activation) of Pgp
4) Confidence 0.09 Published 2007 Journal Nutr J Section Body Doc Link PMC2147024 Disease Relevance 0 Pain Relevance 0.11

General Comments

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