INT91712

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Context Info
Confidence 0.80
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.00
Pain Relevance 5.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Prok2) extracellular region (Prok2)
Anatomy Link Frequency
neurons 2
skin 2
primary sensory neurons 2
neutrophils 2
macrophages 1
Prok2 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 182 100.00 Very High Very High Very High
Hyperalgesia 38 99.88 Very High Very High Very High
Inflammation 103 99.64 Very High Very High Very High
cytokine 49 97.56 Very High Very High Very High
substance P 7 97.52 Very High Very High Very High
central sensitization 21 96.04 Very High Very High Very High
Dorsal horn 7 94.04 High High
withdrawal 56 93.72 High High
Spinal cord 15 93.44 High High
IPN 43 90.32 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 182 100.00 Very High Very High Very High
Hyperalgesia 46 99.88 Very High Very High Very High
INFLAMMATION 146 99.64 Very High Very High Very High
Neurogenic Inflammation 14 96.88 Very High Very High Very High
Nociception 217 95.84 Very High Very High Very High
Injury 15 92.96 High High
Inflammatory Pain 43 90.32 High High
Pain 84 89.72 High High
Targeted Disruption 1 88.72 High High
Hypersensitivity 8 51.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Particularly, PK2 may be released by neutrophils, macrophages at sites of inflammation [15].
Localization (released) of PK2 in macrophages associated with inflammation
1) Confidence 0.80 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.24 Pain Relevance 0.66
Thus, it is probably that PK2 can be released from the terminals of the primary sensory neurons, just like substance P, in neurogenic inflammation.
Localization (released) of PK2 in primary sensory neurons associated with inflammation, neurogenic inflammation and substance p
2) Confidence 0.80 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.17 Pain Relevance 0.67
This result suggested that PK2 might be released from terminals of DRG neurons.


Localization (released) of PK2 in neurons associated with dorsal root ganglion
3) Confidence 0.80 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.90 Pain Relevance 0.63
Mobilization of calcium in DRG neurons by PK2
Localization (Mobilization) of PK2 in neurons associated with dorsal root ganglion
4) Confidence 0.75 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.20 Pain Relevance 0.88
Thus, a reasonable explanation for the reduced late-phase response in PK2-/- mice could be that, PK2 is released from the central afferent terminals of primary sensory neurons after formalin injection, and, cause central sensitization by activating PKRs in the dorsal horn of spinal cord.
Localization (released) of PK2 in primary sensory neurons associated with central sensitization, dorsal horn and spinal cord
5) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.60 Pain Relevance 0.87
At the sites of inflammation, neutrophils may release PK2 that can subsequently induce the release of proinflammatory cytokines like interleukin-1 and interleukin-12 from macrophage or other cells [15].
Localization (release) of PK2 in neutrophils associated with inflammation and cytokine
6) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.13 Pain Relevance 0.86
Bv8 was isolated from skin secretions of the frog Bombina variegata, and was purified to 98% as assessed by means of HPLC [1].


Localization (secretions) of Bv8 in skin
7) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.24 Pain Relevance 0.33
Particularly, PK2 may be released by neutrophils, macrophages at sites of inflammation [15].
Localization (released) of PK2 in neutrophils associated with inflammation
8) Confidence 0.27 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.24 Pain Relevance 0.66
The murine Bv8 gene was shown to consist of four exons and was localized on chromosome 6 between the microsatellite markers D6Mit66 and D6Mit36 near the gene mem1, whereas the human counterpart was assigned to the non-syntenic region 3p21.1.
Localization (localized) of Bv8
9) Confidence 0.25 Published 2000 Journal Gene Section Abstract Doc Link 11054548 Disease Relevance 0.10 Pain Relevance 0.10
The genomic structure of the murine Bv8 gene was determined in 129/SvJ mouse, and the chromosomal localization was identified.
Localization (localization) of Bv8
10) Confidence 0.23 Published 2000 Journal Gene Section Abstract Doc Link 11054548 Disease Relevance 0.09 Pain Relevance 0.09
Bv8 has first been characterized from skin secretion of the yellow-bellied toad, Bombina variegata.
Localization (secretion) of Bv8 in skin
11) Confidence 0.20 Published 2000 Journal Gene Section Abstract Doc Link 11054548 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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