INT91721

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2000
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 21.17
Pain Relevance 6.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
plaque 1
ciliary 1
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 330 100.00 Very High Very High Very High
Inflammation 243 99.68 Very High Very High Very High
rheumatoid arthritis 908 98.80 Very High Very High Very High
Arthritis 30 94.44 High High
Angina 44 94.36 High High
cva 1 92.12 High High
Multiple sclerosis 7 91.24 High High
metalloproteinase 8 81.76 Quite High
Central nervous system 7 75.00 Quite High
ischemia 26 61.28 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 561 100.00 Very High Very High Very High
Necrosis 41 100.00 Very High Very High Very High
Cancer 31 100.00 Very High Very High Very High
Leukemia 2 100.00 Very High Very High Very High
Atherosclerosis 64 99.96 Very High Very High Very High
Appetite Loss 21 99.96 Very High Very High Very High
Arthritis 23 99.68 Very High Very High Very High
Rheumatoid Arthritis 908 98.80 Very High Very High Very High
Death 34 98.68 Very High Very High Very High
Angina 34 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This evidence may indicate a high reproducibility of the genetic associations with GCA among different populations and that the potential association with IL18 may be also found in other populations.
IL18 Binding (association) of associated with increased venous pressure under development
1) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.94 Pain Relevance 0.03
Interestingly, a significant association between biopsy-proven GCA and the IL18-1297 T>C was also found.
IL18 Binding (association) of associated with increased venous pressure under development
2) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.74 Pain Relevance 0
IL18 gene polymorphisms are not associated with clinical manifestation of GCA patients
IL18 gene Binding (associated) of associated with increased venous pressure under development
3) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 1.02 Pain Relevance 0
A logistic regression model was used to estimate gene-gene interaction between the IL18 and TLR4 SNPs and for the additive effects of the three SNPs.
IL18 Binding (interaction) of
4) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.23 Pain Relevance 0
Specific primer for TWEAK [32], IL-18 [5], TGF-?
IL-18 Binding (primer) of
5) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0
In keeping with the results derived from a study on Spanish individuals diagnosed with rheumatoid arthritis (RA) [59], in the present study, we did not find a significant association between the IL18 -137 (rs187238) polymorphism and biopsy-proven GCA.
IL18 Neg (not) Binding (association) of associated with rheumatoid arthritis and increased venous pressure under development
6) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 1.45 Pain Relevance 0.26
Moreover, our data show an additional association of biopsy-proven GCA with IL18 -1297 T>C (rs360719).
IL18 Binding (association) of associated with increased venous pressure under development
7) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 1.36 Pain Relevance 0.21
No significant association between the IL18-137 G>C polymorphism and GCA was found.
IL18 Neg (No) Binding (association) of associated with increased venous pressure under development
8) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888200 Disease Relevance 0.65 Pain Relevance 0
Exogenous IL-18 increased IL-12-induced IFN-?
IL-18 Binding (Exogenous) of
9) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.83 Pain Relevance 0.38
IL-18BP, though it lacks significant homology with IL-18 receptor components, can bind to IL-18 protein with high affinity, thereby acting as a soluble decoy receptor [22,23].
IL-18 Binding (bind) of
10) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.48 Pain Relevance 0.31
than H-PBMCs in response to IL-12 alone or combined with IL-18 when results were expressed as concentrations.


IL-18 Binding (combined) of
11) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.90 Pain Relevance 0.45
A specific inhibitor of IL-18 bioactivity, IL-18-binding protein (IL-18BP), down-regulated IL-12-induced IFN-?
IL-18 Binding (binding) of
12) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.18 Pain Relevance 0.58
A specific inhibitor of IL-18 bioactivity, IL-18-binding protein (IL-18BP), down-regulated IL-12-induced IFN-?
IL-18 Binding (bioactivity) of
13) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.17 Pain Relevance 0.58
A specific inhibitor of IL-18 bioactivity, IL-18-binding protein (IL-18BP), down-regulated IL-12-induced IFN-?
IL-18 Binding (binding) of
14) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.17 Pain Relevance 0.58
Exogenous IL-18 slightly augmented the IL-12-induced IFN-?
IL-18 Binding (Exogenous) of
15) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.79 Pain Relevance 0.40
production by these cells by neutralizing the endogenously produced IL-18, indicating the importance of endogenous IL-18 in IFN-?
IL-18 Binding (endogenous) of
16) Confidence 0.30 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.98 Pain Relevance 0.51
Cytokines are proposed to participate in the development and/or progression of cachexia-anorexia; interleukin-1, interleukin-6 (and its subfamily members such as ciliary neurotrophic factor and leukemia inhibitory factor), interferon-gamma, tumor necrosis factor-alpha, and brain-derived neurotrophic factor have been associated with various cachectic conditions.
interleukin-1 Binding (associated) of in ciliary associated with appetite loss, necrosis, leukemia, cancer and cytokine
17) Confidence 0.11 Published 2000 Journal Nutrition Section Abstract Doc Link 11054608 Disease Relevance 1.84 Pain Relevance 0.38
Combined determination of MMP-9 and IL-18 identifies patients at very high risk.
IL-18 Spec (determination) Binding (determination) of
18) Confidence 0.09 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.89 Pain Relevance 0.57
IL-18 plays a central role in orchestrating the cytokine cascade and accelerates atherosclerosis and plaque vulnerability in animal models.
IL-18 Binding (accelerates) of in plaque associated with atherosclerosis and cytokine
19) Confidence 0.09 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.77 Pain Relevance 0.33
Interleukin-1 receptors
Interleukin-1 Binding (receptors) of
20) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.84 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox