INT91739

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.89
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MYLK) cytoskeleton (MYLK) enzyme binding (MYLK)
kinase activity (MYLK) cytoplasm (MYLK)
Anatomy Link Frequency
smooth muscle 2
filaments 1
MYLK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 69 99.28 Very High Very High Very High
Inflammation 162 99.08 Very High Very High Very High
Morphine 4 98.06 Very High Very High Very High
cocaine 2 91.12 High High
Serotonin 6 87.12 High High
agonist 40 85.92 High High
Dismenorea 4 85.60 High High
alcohol 2 85.04 High High
opiate 3 80.52 Quite High
withdrawal 4 77.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 185 99.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 119 95.32 Very High Very High Very High
Infection 94 88.80 High High
Asthma 145 85.80 High High
Dysmenorrhea 4 85.60 High High
Stress 55 85.20 High High
Cv General 3 Under Development 56 72.48 Quite High
Spasticity 8 68.44 Quite High
Muscular Dystrophy 2 60.84 Quite High
Muscle Disease 1 59.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine and/or tat, via the activation of pro-inflammatory cytokines, intracellular Ca(2+) release, and activation of myosin light chain kinase, modulated TJ expression resulting in decreased transendothelial electric resistance and enhanced transendothelial migration across the BBB.
Positive_regulation (activation) of myosin light chain kinase associated with inflammation, cytokine and morphine
1) Confidence 0.54 Published 2008 Journal J. Clin. Immunol. Section Abstract Doc Link 18574677 Disease Relevance 0.64 Pain Relevance 0.59
The Ca2+/calmodulin complex then activates MLCK, with subsequent phosphorylation of myosin light chain.60) Thus, the more intracellular Ca2+ concentration is increased, the more contraction of vascular smooth muscle will occur.
Positive_regulation (activates) of MLCK in smooth muscle
2) Confidence 0.25 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 0.33 Pain Relevance 0.19
activation to evoke calcium (Ca2+) -dependent activation of myosin light chain kinase (MLCK) and MLC20 phosphorylation [1,2], they may also engage the Ca2+-independent pathway involving receptor co-coupling to G12 and RhoA signalling [1].
Positive_regulation (activation) of MLCK
3) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.04
activation to evoke calcium (Ca2+) -dependent activation of myosin light chain kinase (MLCK) and MLC20 phosphorylation [1,2], they may also engage the Ca2+-independent pathway involving receptor co-coupling to G12 and RhoA signalling [1].
Positive_regulation (activation) of myosin light chain kinase
4) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.04
Estrogens increase the expression of many contraction-associated proteins, including connexin 43, and of oxytocin and prostaglandin receptors; estrogens also promote prostaglandin production and increases myosin light-chain kinase (MLCK, which stimulates myometrial contractions) [3].
Positive_regulation (increases) of myosin light-chain kinase
5) Confidence 0.21 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.09 Pain Relevance 0.12
exposure has been reported to activate myosin light chain kinase, indicating that stimuli present in inflamed airways may be able to influence actin-myosin cycling [75].
Positive_regulation (activate) of myosin light chain kinase
6) Confidence 0.13 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.34 Pain Relevance 0.20
The CFS-induced modulation of TJ barrier was associated with activation of myosin light chain kinase (MLCK) activity and centripetal retraction of peri-junctional actin and myosin filaments.
Positive_regulation (activation) of myosin light chain kinase in filaments
7) Confidence 0.10 Published 2000 Journal Microsc. Res. Tech. Section Abstract Doc Link 11054866 Disease Relevance 0.21 Pain Relevance 0.08
HIV Tat and morphine apparently cooperate in diminishing the electrical resistance and increasing the transmigration across the BBB via the activation of pro-inflammatory cytokines, the stimulation of intracellular Ca2+ release, and the activation of myosin light chain kinase [131].
Positive_regulation (activation) of myosin light chain kinase associated with inflammation, acquired immune deficiency syndrome or hiv infection, cytokine and morphine
8) Confidence 0.05 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.94 Pain Relevance 0.31
-sarcoglycan; and dystrophin increased 6- to 8-fold in 4-day serum-deprived human ASM cultures; concomitant accumulation of smooth muscle myosin (smMHC) and calponin, established markers of the contractile phenotype, was also induced with 4 days of serum deprivation.
Positive_regulation (accumulation) of smooth muscle myosin in smooth muscle
9) Confidence 0.01 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.18 Pain Relevance 0

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